Carvedilol in patients with compensated cirrhosis: The ongoing benefits of definitive randomised trials over meta-analysis in patients with small varices

Affiliations

¹ Institute of Liver Studies, Department of Inflammation Biology, Kings College London, London, UK; Institute of Liver Studies, Kings College Hospital, Denmark Hill, London, UK. Electronic address: mark.mcphail@kcl.ac.uk.
² Institute of Liver Studies, Department of Inflammation Biology, Kings College London, London, UK; Institute of Liver Studies, Kings College Hospital, Denmark Hill, London, UK; Roger Williams Institute of Hepatology, London, UK.
³ Department of Biostatistics, Kings College London, London, UK.

Meta-Analysis

Mark J W McPhail et al. J Hepatol. 2023 Jul.

. 2023 Jul;79(1):e21-e23.

doi: 10.1016/j.jhep.2022.12.019. Epub 2022 Dec 31.

¹ Institute of Liver Studies, Department of Inflammation Biology, Kings College London, London, UK; Institute of Liver Studies, Kings College Hospital, Denmark Hill, London, UK. Electronic address: mark.mcphail@kcl.ac.uk.
² Institute of Liver Studies, Department of Inflammation Biology, Kings College London, London, UK; Institute of Liver Studies, Kings College Hospital, Denmark Hill, London, UK; Roger Williams Institute of Hepatology, London, UK.
³ Department of Biostatistics, Kings College London, London, UK.

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Reply to: "Carvedilol in patients with compensated cirrhosis: The ongoing benefits of definitive randomised trials over meta-analysis in patients with small varices".
Villanueva C, Torres F, Tripathi D, Bosch J; Carvedilol-IPD-MA-group. Villanueva C, et al. J Hepatol. 2023 Jul;79(1):e23-e24. doi: 10.1016/j.jhep.2023.02.025. Epub 2023 Feb 25. J Hepatol. 2023. PMID: 36848975 No abstract available.

Carvedilol reduces the risk of decompensation and mortality in patients with compensated cirrhosis in a competing-risk meta-analysis.
Villanueva C, Torres F, Sarin SK, Shah HA, Tripathi D, Brujats A, Rodrigues SG, Bhardwaj A, Azam Z, Hayes PC, Jindal A, Abid S, Alvarado E, Bosch J; Carvedilol-IPD-MA-group and the Baveno Cooperation: an EASL Consortium. Villanueva C, et al. J Hepatol. 2022 Oct;77(4):1014-1025. doi: 10.1016/j.jhep.2022.05.021. Epub 2022 May 31. J Hepatol. 2022. PMID: 35661713