Amitriptyline intoxication in bullfrogs causes widening of QRS complexes in electrocardiogram
- PMID: 36596558
- PMCID: PMC10017290
- DOI: 10.1292/jvms.22-0494
Amitriptyline intoxication in bullfrogs causes widening of QRS complexes in electrocardiogram
Abstract
Amitriptyline intoxication is caused by its suicidal or accidental overdose. In the present study, by intravenously injecting 1.5 or 3.0 mg/kg amitriptyline into bullfrogs, we actually revealed that amitriptyline causes the widening of QRS complexes in electrocardiogram (ECG). In simultaneous recordings of the cardiac action potential, amitriptyline decreased the slope of phase 0 in the action potential, indicating the inhibition of the inward sodium currents during this phase. The following treatment with sodium bicarbonate quickly restored the widened QRS complexes in the ECG, demonstrating the counteraction with the sodium channel blockade caused by amitriptyline. The dual recordings of ECG waveforms and the action potential in cardiomyocytes enabled us to demonstrate the mechanisms of characteristic ECG abnormalities caused by amitriptyline intoxication.
Keywords: amitriptyline; bullfrog heart; cardiac action potential; electrocardiogram (ECG); widening of QRS complexes.
Conflict of interest statement
The authors have nothing to disclose.
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