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. 2022 Dec;54(4):792-796.
doi: 10.3947/ic.2022.0110.

Co-Infection in COVID-19 Pneumonia: Discussion Continues

Daria Strelkova  1 , Svetlana Rachina  2 , Alexey Klimenko  3 , Svetlana Yatsyshina  4 , Dmitry Cheboksarov  5 , Tatiana Cherkasova  6 , Natig Ramazanov  2 , Nataliia Ananicheva  7
Affiliations

Co-Infection in COVID-19 Pneumonia: Discussion Continues

Daria Strelkova et al. Infect Chemother. 2022 Dec.

Abstract

Sixty-six patients with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 and pneumonia on chest computer tomography were prospectively recruited. A combined respiratory swab for polymerase chain reaction (PCR), urine sample for pneumococcal and Legionella antigen, and sputum or endotracheal aspirate were collected. Urinary antigen and blood culture tests were negative in all cases as well as the PCR tests for other respiratory viruses and atypical bacterial pathogens. In total, 5 patients (7.5%) had co-infection. By PCR a high prevalence of colonization with bacterial pathogens was found. In conclusion, co-infection is rare in coronavirus disease 2019 patients, and additional examination to identify other pathogens should be performed only in selected cases.

Keywords: Antibiotics; COVID-19; Co-infection; Pneumonia; SARS-CoV-2.

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Conflict of interest statement

No conflict of interest.

References

    1. Johns Hopkins University & Medicine. Coronavirus resource center. COVID-19 Dashboard. [Accessed 10 July 2022]. Available at: https://coronavirus.jhu.edu/map.html.
    1. Langford BJ, So M, Raybardhan S, Leung V, Westwood D, MacFadden DR, Soucy JR, Daneman N. Bacterial co-infection and secondary infection in patients with COVID-19: a living rapid review and meta-analysis. Clin Microbiol Infect. 2020;26:1622–1629. - PMC - PubMed
    1. Lansbury L, Lim B, Baskaran V, Lim WS. Co-infections in people with COVID-19: a systematic review and meta-analysis. J Infect. 2020;81:266–275. - PMC - PubMed
    1. Rawson TM, Moore LSP, Zhu N, Ranganathan N, Skolimowska K, Gilchrist M, Satta G, Cooke G, Holmes A. Bacterial and fungal coinfection in individuals with coronavirus: a rapid review to support COVID-19 antimicrobial rescribing. Clin Infect Dis. 2020;71:2459–2468. - PMC - PubMed
    1. Vaughn VM, Gandhi TN, Petty LA, Patel PK, Prescott HC, Malani AN, Ratz D, McLaughlin E, Chopra V, Flanders SA. Empiric antibacterial therapy and community-onset bacterial coinfection in patients hospitalized with coronavirus disease 2019 (COVID-19): a multi-hospital cohort study. Clin Infect Dis. 2021;72:e533–e541. - PMC - PubMed