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. 2023 Jan 4;408(1):6.
doi: 10.1007/s00423-022-02741-z.

Prognostic implications of histologic growth patterns and tumor-infiltrating macrophages in colorectal liver metastases

Yuki Takahashi  1 , Kenichi Matsuo  1   2 , Toshimitsu Shiozawa  1 , Kaori Suzuki  1 , Hiroaki Shimizu  2 , Kuniya Tanaka  3   4
Affiliations

Prognostic implications of histologic growth patterns and tumor-infiltrating macrophages in colorectal liver metastases

Yuki Takahashi et al. Langenbecks Arch Surg. .

Erratum in

Abstract

Purpose: Histopathologic patterns at the invasion fronts of tumors predict metastatic potential and prognosis in several cancers. We examined whether such patterns at the interface between colorectal liver metastases and hepatic parenchyma have similar prognostic value.

Methods: Microscopic growth patterns at edges of metastases including desmoplasia, pushing borders, and replacement of hepatocytes were retrospectively analyzed with respect to surgical outcomes in 142 patients who underwent hepatectomy for colorectal metastases.

Results: Patterns included desmoplasia in 58 patients (41%), hepatocyte replacement in 41 (29%), and pushing borders in 43 (30%). Maximum metastasis diameter and serum carcinoembryonic antigen concentration in patients showing desmoplastic tumor growth were lower than those in others (P < 0.05 and P < 0.01). Disease-free survival and overall survival were better in patients showing desmoplastic growth, while a non-desmoplastic tumor growth pattern showed a negative influence. More cluster of differentiation (CD) 68-positive M1 macrophages and fewer CD206-positive M2 macrophages were demonstrated at interfaces of tumors with hepatic parenchyma when desmoplasia was present, although markers for proliferative activity (MIB1 index) and metastatic potential (E-cadherin expression) appeared uninfluenced by desmoplasia.

Conclusion: Better long-term results were associated with metastatic tumors showing desmoplastic growth patterns at invasion fronts, which may reflect local immune state in a prognostically useful manner.

Keywords: Colorectal cancer; Hepatectomy; Liver metastases; Tumor growth pattern.

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References

    1. Van den Eynden GG, Bird NC, Majeed AW, Van LS, Dirix LY, Vermeulen PB (2012) The histological growth pattern of colorectal cancer liver metastases has prognostic value. Clin Exp Metastasis 29:541–549 - PubMed
    1. Pinheiro RS, Herman P, Lupinacci RM, Lai Q, Mello ES, Coelho FF, Perini MV, Pugliese V, Andraus W, Cecconello I, D’Albuquerque LC (2014) Tumor growth pattern as predictor of colorectal liver metastasis recurrence. Am J Surg 207:493–498 - PubMed
    1. Okano K, Yamamoto J, Kosuge T, Yamamoto S, Sakamoto M, Nakanishi Y, Hirohashi S (2000) Fibrous pseudocapsule of metastatic liver tumors from colorectal carcinoma. Clinicopathologic study of 152 first resection cases. Cancer 89:267–275 - PubMed
    1. Stremitzer S, Vermeulen P, Graver S, Kockx M, Dirix L, Yang D, Zhang W, Stift J, Wrba F, Gruenberger T, Lenz HJ, Scherer SJ (2020) Immune phenotype and histopathological growth pattern in patients with colorectal liver metastases. Br J Cancer 122:1518–1524 - PubMed - PMC
    1. Lunevicius R, Nakanishi H, Ito S, Kozaki K, Kato T, Tatematsu M, Yasui K (2001) Clinicopathological significance of fibrotic capsule formation around liver metastasis from colorectal cancer. J Cancer Res Clin Oncol 127:193–199 - PubMed

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