Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Mar 10;109(7):557-563.
doi: 10.1136/heartjnl-2022-321594.

Changes in aortic valve replacement procedures in Denmark from 2008 to 2020

Peter Laursen Graversen  1 , Jawad Haider Butt  2 , Lauge Østergaard  2 , Andreas Dalsgaard Jensen  2 , Peder Emil Warming  2 , Jarl Emanuel Strange  2 , Christian H Møller  3   4 , Morten Schou  4   5 , Ole De Backer  2 , Lars Køber  2   4 , Emil Loldrup Fosbøl  2
Affiliations

Changes in aortic valve replacement procedures in Denmark from 2008 to 2020

Peter Laursen Graversen et al. Heart. .

Abstract

Introduction: Since 2007, transcatheter aortic valve implantation (TAVI) has emerged as another treatment strategy for severe symptomatic aortic stenosis (AS) compared with surgical aortic valve replacement (SAVR). The objectives were to compare annual rates of aortic valve replacement (AVR) procedures performed in Denmark in the era of TAVI and to assess proportion of AVRs stratified by age with use of age recommendations presented in current guidelines.

Methods: Using Danish nationwide registries, we identified first-time AVRs between 2008 and 2020. Patients who were not diagnosed with AS prior to AVR were excluded RESULTS: The rate of AVRs increased by 39% per million inhabitants from 2008 to 2020. TAVI has steadily increased since 2008, accounting for 64.2% of all AVRs and 72.5% of isolated AVRs by 2020. Number of isolated SAVRs decreased from 2014 and onwards. The proportion of TAVI increased significantly across age groups (<75 and ≥75 years of age, ptrend<0.001), and TAVI accounted for 91.5% of isolated AVR procedures in elderly patients (aged ≥75 years). Length of hospital stay were significantly reduced for all AVRs during the study period (ptrend all<0.001).

Conclusions: The number of AVRs increased from 2008 to 2020 due to adaptation of TAVI, which represented 2/3 of AVRs and more than 70% of isolated AVRs. In elderly patients, the increased use of AVR procedures was driven by TAVI, in agreement with the age recommendations in current guidelines; however, TAVI was used more frequently in patients aged <75 years, accompanied by a flattening use of SAVR.

Keywords: aortic stenosis; epidemiology; heart valve diseases; heart valve prosthesis implantation; transcatheter aortic valve replacement.

PubMed Disclaimer

Conflict of interest statement

Competing interests: PLG: Independent research grant provided by the Novo Nordisk Foundation for research in valvular heart disease. However, the foundation did not have any influence on the study design, data acquisition, data analysis or preparation of the manuscript. Neither had it any effect on the publication process. JHB: reports advisory board honoraria from Bayer, outside the submitted work. MS: Lecture fee Novo, Novartis, Bohringer Ingelheim and Astra Zeneca. ODB: received institutional research grants and consulting fees from Abbott and Boston Scientific. LK: Speakers honorarium from Nova, Novartis, AstraZeneca, Bayer and Boehringer, unrelated to this manuscript. ELF: an independent research grant provided by the Novo Nordisk Foundation for research in valvular heart disease.

Comment in

LinkOut - more resources