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. 2023 Jan 19;59(7):888-891.
doi: 10.1039/d2cc06602e.

Highly inert Cu(II) complexes of C-aryl bifunctional cyclam-picolinates with remarkable 64Cu-labelling and biodistribution

Julie Pineau  1 , Luís M P Lima  2 , Marie M Le Roy  1 , Séverine Marionneau-Lambot  3 , Marie Cordier  4 , Patricia Le Saëc  3 , Jan Rijn Zeevaart  5 , Cathryn H S Driver  5 , Alain Faivre-Chauvet  3 , Nathalie Le Bris  1 , Raphaël Tripier  1
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Highly inert Cu(II) complexes of C-aryl bifunctional cyclam-picolinates with remarkable 64Cu-labelling and biodistribution

Julie Pineau et al. Chem Commun (Camb). .

Abstract

Cyclam-picolinate chelators were functionalized via click chemistry with an additional carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding 64Cu-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chemical properties of the radiocomplexes whilst deeply enhancing their applications within nuclear medicine.

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