[Sedation of critically ill patients with dexmedetomidine]
- PMID: 36598530
- DOI: 10.1007/s00101-022-01244-2
[Sedation of critically ill patients with dexmedetomidine]
Comment on
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Early Sedation with Dexmedetomidine in Critically Ill Patients.N Engl J Med. 2019 Jun 27;380(26):2506-2517. doi: 10.1056/NEJMoa1904710. Epub 2019 May 19. N Engl J Med. 2019. PMID: 31112380 Clinical Trial.
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Early sedation with dexmedetomidine in ventilated critically ill patients and heterogeneity of treatment effect in the SPICE III randomised controlled trial.Intensive Care Med. 2021 Apr;47(4):455-466. doi: 10.1007/s00134-021-06356-8. Epub 2021 Mar 8. Intensive Care Med. 2021. PMID: 33686482 Free PMC article. Clinical Trial.
References
Literatur
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- Rote Hand Brief „Dexmedetomidin: Risiko von erhöhter Mortalität bei Intensivpatienten ≤ 65 Jahren“ vom 15.06.2022. https://www.bfarm.de/SharedDocs/Risikoinformationen/Pharmakovigilanz/DE/... . Zugegriffen: 30. Aug. 2022
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- (2020) AWMF, S3-Leitlinie „Analgesie, Sedierung und Delirmanagement in der Intensivmedizin“. https://www.awmf.org/uploads/tx_szleitlinien/001-012l_S3_Analgesie-Sedie... . Zugegriffen: 18. Okt. 2022
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- Shehabi Y, Serpa Neto A, Bellomo R et al (2022) SPICE III study investigators. Dexmedetomidine and propofol sedation in critically Ill patients and dose associated 90-day mortality: a secondary cohort analysis of a randomized controlled trial (SPICE-III). Am J Respir Crit Care Med. https://doi.org/10.1164/rccm.202206-1208OC - DOI - PubMed
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- Heybati K, Zhou F, Ali S et al (2022) Outcomes of dexmedetomidine versus propofol sedation in critically ill adults requiring mechanical ventilation: a systematic review and meta-analysis of randomised controlled trials. Br J Anaesth 129(4):515–526. https://doi.org/10.1016/j.bja.2022.06.020 - DOI - PubMed
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