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. 2023 Jan 1;45(1):e150-e153.
doi: 10.1097/MPH.0000000000002539. Epub 2022 Dec 13.

Hepatitis E Virus Infection in Pediatric Oncology

Anna Lenglart  1 , Céline Chappé  1 , Isabelle Grulois  2 , Françoise Hervé  3 , Virginie Gandemer  1   4   5 , Guillaume Robert  1   5
Affiliations

Hepatitis E Virus Infection in Pediatric Oncology

Anna Lenglart et al. J Pediatr Hematol Oncol. .

Abstract

Background: In the 2016 ESPGHAN recommendations on how to deal with hepatitis E virus infection in immunocompromised children, patients treated with chemotherapy were not specifically mentioned.

Observations: Two teenagers treated with chemotherapy for acute leukemia and medulloblastoma, respectively, were diagnosed with hepatic cytolysis. After numerous investigations hepatitis E was found, limiting the good progress of the chemotherapy treatment.

Conclusion: In the case of liver cytolysis in immunocompromised children treated with chemotherapy, hepatitis E virus infection has to be promptly diagnosed.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Colson P, Coze C. Transfusion-associated hepatitis E, France. Emerg Infect Dis. 2007;13:647.
    1. Motte A, Roquelaure B, Galambrun C, et al. Hepatitis E in three immunocompromized children in southeastern France. J Clin Virol. 2012;53:162–166.
    1. Blasco Perrin H, Abravanel F, Péron JM. Hepatitis E Virus in France, recent epidemiological and clinical data. Hépato Gastro. 2015;22:795–802.
    1. Kamar N, Sleves J, Mansuy JM, et al. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N Engl J Med. 2008;358:811–817.
    1. Kamar N, Izopet J, Tripon S, et al. Ribavirin for chronic hepatitis E virus infection in transplant recipients. N Engl J Med. 2014;370:1111–1120.