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. 2023 Mar 15;207(6):792-795.
doi: 10.1164/rccm.202210-1938LE.

Moving the Dial on Airway Inflammation in Response to Trikafta in Adolescents with Cystic Fibrosis

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Moving the Dial on Airway Inflammation in Response to Trikafta in Adolescents with Cystic Fibrosis

Agathe Lepissier et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Concentration of sputum NE, IL-1β, IL-8, and blood CRP, PMN, and leukocyte counts at baseline (M0) and M1 treatment with elexacaftor, tezacaftor, and ivacaftor. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001. CRP = C-reactive protein; M0 = month 0; M1 = month 1; NE = neutrophil elastase; PMN = polymorphonuclear neutrophil.

References

    1. Cohen-Cymberknoh M, Kerem E, Ferkol T, Elizur A. Airway inflammation in cystic fibrosis: molecular mechanisms and clinical implications. Thorax . 2013;68:1157–1162. - PubMed
    1. Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF, Polineni D, et al. VX17-445-102 Study Group Elexacaftor-tezacaftor-ivacaftor for cystic fibrosis with a single Phe508del allele. N Engl J Med . 2019;381:1809–1819. - PMC - PubMed
    1. McElvaney OJ, Gunaratnam C, Reeves EP, McElvaney NG. A specialized method of sputum collection and processing for therapeutic interventions in cystic fibrosis. J Cyst Fibros . 2019;18:203–211. - PubMed
    1. Margaroli C, Garratt LW, Horati H, Dittrich AS, Rosenow T, Montgomery ST, et al. Elastase exocytosis by airway neutrophils is associated with early lung damage in children with cystic fibrosis. Am J Respir Crit Care Med . 2019;199:873–881. - PMC - PubMed
    1. Lepissier A, Addy C, Hayes K, Noel S, Bui S, Burgel PR, et al. Inflammation biomarkers in sputum for clinical trials in cystic fibrosis: current understanding and gaps in knowledge. J Cyst Fibros . 2022;21:691–706. - PubMed

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