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Comment
. 2023 Jan 3;35(1):3-5.
doi: 10.1016/j.cmet.2022.12.009.

Early immune pressure makes tumors metabolically stronger

Sujing Yuan  1 , Hongbo Chi  2
Affiliations
Free article
Comment

Early immune pressure makes tumors metabolically stronger

Sujing Yuan et al. Cell Metab. .
Free article

Abstract

Metabolic communication in the tumor microenvironment underscores tumor-immune interactions and affects anti-tumor immunity, yet cell-extrinsic signals driving tumor metabolic remodeling are incompletely understood. In this issue, Tsai et al. show that during initial tumorigenesis, T cell-derived IFNγ triggers STAT3 activation and c-Myc-dependent alterations of tumor cell metabolism, which potentiates immune evasion.

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Conflict of interest statement

Declaration of interests H.C. is a consultant for Kumquat Biosciences, Inc.

Comment on

  • Immunoediting instructs tumor metabolic reprogramming to support immune evasion.
    Tsai CH, Chuang YM, Li X, Yu YR, Tzeng SF, Teoh ST, Lindblad KE, Di Matteo M, Cheng WC, Hsueh PC, Kao KC, Imrichova H, Duan L, Gallart-Ayala H, Hsiao PW, Mazzone M, Ivanesevic J, Liu X, de Visser KE, Lujambio A, Lunt SY, Kaech SM, Ho PC. Tsai CH, et al. Cell Metab. 2023 Jan 3;35(1):118-133.e7. doi: 10.1016/j.cmet.2022.12.003. Cell Metab. 2023. PMID: 36599297 Free PMC article.

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