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Comment
. 2023 Jan 3;35(1):7-9.
doi: 10.1016/j.cmet.2022.12.008.

Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet

Paramita Pati  1 , Jennifer S Pollock  1 , Karen L Gamble  2
Affiliations
Comment

Timed feeding aligns the adipocyte clock to optimize thermogenesis when eating a high-fat diet

Paramita Pati et al. Cell Metab. .

Abstract

The timing of food intake is vital for metabolic health in obesity. A recent study in mice from Hepler et al. in Science shows the importance of the adipocyte circadian clock in metabolic health, highlighting the creatine pathway and thermogenesis with the alignment of the timing of high-fat feeding.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1.
Figure 1.
Translational implications for dietary interventions in humans based on evidence from mice The adipocyte circadian clock regulates creatine metabolism and thermogenesis. Left: Daytime meals including HFD (aligned) may increase energy expenditure and metabolic health through adipocyte thermogenesis. Right: Nighttime HFD consumption (misaligned) impairs metabolism through decreased energy expenditure and thermogenesis.
See this image and copyright information in PMC

Comment on

References

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