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. 2022 Dec;9(1):e000688.
doi: 10.1136/lupus-2022-000688.

Black patients with cutaneous lupus are associated with positive family history of cutaneous lupus and systemic lupus

Heejo Keum  1 , L Steven Brown  2 , Benjamin F Chong  3
Affiliations

Black patients with cutaneous lupus are associated with positive family history of cutaneous lupus and systemic lupus

Heejo Keum et al. Lupus Sci Med. 2022 Dec.

Abstract

Objectives: Various genetic polymorphisms have been associated with an increased risk of cutaneous lupus erythematosus (CLE). However, it is not fully known how often positive family histories occur in patients with CLE. The aims of this study are to determine the rate of positive family history among patients with CLE and to identify risk factors associated with positive family history.

Methods: A retrospective cohort study was conducted among 338 patients with CLE seen in outpatient dermatology clinics in a tertiary referral centre in Dallas, Texas. The primary outcome was positive family history of CLE and/or SLE, as defined by the presence of self-reported CLE and/or SLE in first-degree or more distant relatives of a patient. Univariate analyses were performed to identify risk factors associated with positive family history of CLE and/or SLE in patients with CLE. Multivariable logistic regression analyses were performed to determine significant predictors of positive family history of CLE and/or SLE.

Results: 34% (n=114) of patients reported positive family history of CLE and/or SLE. 7% (n=23) of patients with CLE had relatives with CLE, with 5% (n=18) having a first-degree relative with CLE. 30% (n=102) of patients with CLE had relatives with SLE, and 15% (n=52) had a first-degree relative with SLE. Black patients were more likely to have positive family history of CLE and/or SLE (OR 2.13, 95% CI 1.23 to 3.69, p=0.007).

Conclusions: More patients with CLE had positive family history of SLE than CLE. Black patients with CLE were more likely to have a relative with CLE and/or SLE. Providers can use this information to counsel patients with CLE on the risk of other family members having CLE and/or SLE. These data may help identify potentially new genetic polymorphisms associated with positive family history.

Keywords: Autoimmune Diseases; Lupus Erythematosus, Systemic; Systemic Lupus Erythematosus.

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Conflict of interest statement

Competing interests: BFC is an investigator for Daavlin Corporation, Biogen and Pfizer. He is a consultant for Bristol Meyers Squibb, EMD Serono, Horizon Therapeutics and Biogen. BFC receives royalties from MAPI Research Trust. The other authors have no conflicts of interest.

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