Clinical and patient-reported outcome profile of patients with hepatitis B viral infection from the Global Liver Registry™

Zobair M Younossi^{1

2

3}, Ming-Lung Yu^{4

5}, Yusuf Yilmaz^{6

7}, Khalid Aida Alswat⁸, Maria Buti⁹, Marlen Ivon Castellanos Fernandez¹⁰, Georgios Papatheodoridis¹¹, Saeed S Hamid¹², Mohamed El-Kassas¹³, Wah Kheong Chan¹⁴, Ajay K Duseja¹⁵, Stuart C Gordon¹⁶, Yuichiro Eguchi¹⁷, Vasily A Isakov¹⁸, Stuart K Roberts^{19

20}, Jian-Gao Fan²¹, Ashwani K Singal²², Manuel Romero-Gómez²³, Aijaz Ahmed²⁴, Janus Ong²⁵, Brian P Lam^{1

2

3}, Issah Younossi²⁶, Fatema Nader²⁶, Andrei Racila²⁶, Maria Stepanova^{1

2

3

26}, Saleh Alqahtani^{26

27}

Affiliations

¹ Center for Liver Diseases, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.
² Inova Medicine Service Line, Inova Health System, Falls Church, Virginia, USA.
³ Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia, USA.
⁴ School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.
⁵ Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁶ Liver Research Unit, Institute of Gastroenterology, Marmara University, İstanbul, Turkey.
⁷ Department of Gastroenterology, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
⁸ Liver Disease Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
⁹ Liver Unit, Universitario Vall d'Hebron and CIBEREHD del Instituto Carlos III, Barcelona, Spain.
¹⁰ Institute of Gastroenterology, University of Medical Science, Havana, Cuba.
¹¹ Academic Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School of the National and Kapodistrian University of Athens, Athens, Greece.
¹² Department of Medicine, Aga Khan University, Karachi, Pakistan.
¹³ Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
¹⁴ Department of Gastroenterology and Hepatology, University of Malaya, Kuala Lumpur, Malaysia.
¹⁵ Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
¹⁶ Department of Hepatology and Gastroenterology, Henry Ford Hospital System, Wayne State University School of Medicine, Detroit, Michigan, USA.
¹⁷ Loco Medical General Institute, Saga, Japan.
¹⁸ Division of Gastroenterology and Hepatology, Federal Research Center of Nutrition and Biotechnology, Moscow, Russia.
¹⁹ Department of Medicine, Monash University, Melbourne, Australia.
²⁰ Department of Gastroenterology and Hepatology, Alfred Health, Melbourne, Australia.
²¹ Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
²² University of South Dakota and Avera Transplant Institute, Sioux Falls, South Dakota, USA.
²³ Digestive Diseases Department, Virgen del Rocío University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville, Spain.
²⁴ Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California, USA.
²⁵ College of Medicine, University of the Philippines, Manila, Philippines.
²⁶ Center for Outcomes Research in Liver Diseases, Washington, DC, USA.
²⁷ King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.

PMID: 36601668
DOI: 10.1111/jvh.13800

Clinical and patient-reported outcome profile of patients with hepatitis B viral infection from the Global Liver Registry™

Zobair M Younossi et al. J Viral Hepat. 2023 Apr.

. 2023 Apr;30(4):335-344.

doi: 10.1111/jvh.13800. Epub 2023 Jan 11.

Authors

Affiliations

¹ Center for Liver Diseases, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, Virginia, USA.
² Inova Medicine Service Line, Inova Health System, Falls Church, Virginia, USA.
³ Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, Virginia, USA.
⁴ School of Medicine, College of Medicine, National Sun Yat-sen University, Kaohsiung, Taiwan.
⁵ Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
⁶ Liver Research Unit, Institute of Gastroenterology, Marmara University, İstanbul, Turkey.
⁷ Department of Gastroenterology, School of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.
⁸ Liver Disease Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
⁹ Liver Unit, Universitario Vall d'Hebron and CIBEREHD del Instituto Carlos III, Barcelona, Spain.
¹⁰ Institute of Gastroenterology, University of Medical Science, Havana, Cuba.
¹¹ Academic Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School of the National and Kapodistrian University of Athens, Athens, Greece.
¹² Department of Medicine, Aga Khan University, Karachi, Pakistan.
¹³ Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt.
¹⁴ Department of Gastroenterology and Hepatology, University of Malaya, Kuala Lumpur, Malaysia.
¹⁵ Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
¹⁶ Department of Hepatology and Gastroenterology, Henry Ford Hospital System, Wayne State University School of Medicine, Detroit, Michigan, USA.
¹⁷ Loco Medical General Institute, Saga, Japan.
¹⁸ Division of Gastroenterology and Hepatology, Federal Research Center of Nutrition and Biotechnology, Moscow, Russia.
¹⁹ Department of Medicine, Monash University, Melbourne, Australia.
²⁰ Department of Gastroenterology and Hepatology, Alfred Health, Melbourne, Australia.
²¹ Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
²² University of South Dakota and Avera Transplant Institute, Sioux Falls, South Dakota, USA.
²³ Digestive Diseases Department, Virgen del Rocío University Hospital, Institute of Biomedicine of Seville, University of Seville, Seville, Spain.
²⁴ Division of Gastroenterology and Hepatology, Stanford University Medical Center, Stanford, California, USA.
²⁵ College of Medicine, University of the Philippines, Manila, Philippines.
²⁶ Center for Outcomes Research in Liver Diseases, Washington, DC, USA.
²⁷ King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.

PMID: 36601668
DOI: 10.1111/jvh.13800

Abstract

Chronic hepatitis B (CHB) infection is one of the most common causes of cirrhosis and liver cancer worldwide. Our aim was to assess clinical and patient-reported outcome (PRO) profile of CHB patients from different regions of the world using the Global Liver Registry. The CHB patients seen in real-world practices are being enrolled in the Global Liver Registry. Clinical and PRO (FACIT-F, CLDQ, WPAI) data were collected and compared to baseline data from CHB controls from clinical trials. The study included 1818 HBV subjects (48 ± 13 years, 58% male, 14% advanced fibrosis, 7% cirrhosis) from 15 countries in 6/7 Global Burden of Disease super-regions. The rates of advanced fibrosis varied (3-24%). The lowest PRO scores across multiple domains were in HBV subjects from the Middle East/North Africa (MENA), the highest - Southeast/East and South Asia. Subjects with advanced fibrosis had PRO impairment in 3 CLDQ domains, Activity of WPAI (p < 0.05). HBV subjects with superimposed fatty liver had more PRO impairments. In multivariate analysis adjusted for location, predictors of PRO impairment in CHB included female sex, advanced fibrosis, and non-hepatic comorbidities (p < 0.05). In comparison to Global Liver Registry patients, 242 controls from clinical trials had better PRO scores (Abdominal, Emotional, and Systemic scores of CLDQ, all domains of WPAI) (p < 0.05). In multivariate analysis with adjustment for location and clinicodemographic parameters, the associations of PROs with the enrollment setting (real-life Global Liver Registry vs. clinical trials) were no longer significant (all p > 0.10). The clinico-demographic portrait of CHB patients varies across regions of the world and enrollment settings. Advanced fibrosis and non-hepatic comorbidities are independently associated with PRO impairment in CHB patients.

Keywords: emotional well-being; fatigue; fatty liver; physical functioning; viral hepatitis; work productivity.

PubMed Disclaimer

References

REFERENCES

1. World Health Organization- Hepatitis B Fast fact. Obtained from the world wide web. https://www.who.int/news-room/fact-sheets/detail/hepatitis-b. Accessed on August 16, 2022.
1. Schillie S, Vellozzi C, Reingold A, et al. Prevention of hepatitis B virus infection in the United States: recommendations of the advisory committee on immunization practices. MMWR Recomm Rep. 2018;67(1):1-31.
1. Paik JM, Golabi P, Younossi Y, Mishra A, Younossi ZM. Changes in the global burden of chronic liver diseases from 2012 to 2017: the growing impact of NAFLD. Hepatology. 2020;72(5):1605-1616.
1. Nguyen MH, Wong G, Gane E, Kao JH, Dusheiko G. Hepatitis B virus: advances in prevention, diagnosis, and therapy. Clin Microbiol Rev. 2020;33(2):e00046-19.
1. Xu B, Lin L, Xu G, et al. Long-term lamivudine treatment achieves regression of advanced liver fibrosis/cirrhosis in patients with chronic hepatitis B. J Gastroenterol Hepatol. 2015;30(2):372-378.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Wiley
Medical
- MedlinePlus Health Information
Research Materials
- NCI CPTC Antibody Characterization Program
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Clinical and patient-reported outcome profile of patients with hepatitis B viral infection from the Global Liver Registry™

Affiliations

Clinical and patient-reported outcome profile of patients with hepatitis B viral infection from the Global Liver Registry™

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Research Materials

Miscellaneous