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Clinical Trial
. 2023 Mar;99(2):140-142.
doi: 10.1136/sextrans-2022-055634. Epub 2022 Dec 8.

Hepatitis A and B vaccine uptake and immunisation among men who have sex with men seeking PrEP: a substudy of the ANRS IPERGAY trial

Paul Le Turnier  1   2   3 , Isabelle Charreau  4 , Audrey Gabassi  5   6 , Diane Carette  4 , Laurent Cotte  7 , Gilles Pialoux  8 , Cécile Tremblay  9 , Bruno Spire  10 , Marie-Laure Chaix  5   6 , Laurence Meyer  4   11 , Catherine Capitant  4 , Constance Delaugerre  5   6 , François Raffi #  12   2 , Jean-Michel Molina #  6   13 ; ANRS IPERGAY study group
Collaborators, Affiliations
Clinical Trial

Hepatitis A and B vaccine uptake and immunisation among men who have sex with men seeking PrEP: a substudy of the ANRS IPERGAY trial

Paul Le Turnier et al. Sex Transm Infect. 2023 Mar.

Abstract

Vaccination against hepatitis A virus (HAV) and hepatitis B virus (HBV) is recommended in men who have sex with men (MSM). We assessed HAV and HBV vaccine uptake in the non-immune participants and their immunisation during follow-up of the ANRS IPERGAY (Intervention Préventive de l'Exposition aux Risques avec et pour les Gays) pre-exposure prophylaxis (PrEP) trial.During the ANRS IPERGAY trial among MSM (NCT01473472), vaccination against HAV and HBV was offered free of charge to all non-immune participants at baseline. We assessed anti-HAV IgGs and anti-hepatitis B surface (HBs) antibodies (Abs) at baseline, 1-3 months after each vaccine dose and on the last follow-up visit. Vaccination uptake and immunisation were analysed in non-immune participants with at least 6 months of follow-up after the 1st vaccine dose.A total of 427 MSM with a median age of 34.8 years were analysed. Median follow-up was 2.2 years (Q1-Q3, 1.6-2.9). Absence of anti-HAV IgG at baseline (50.4%, 215/427) was associated with younger age (p=0.0001). Among HAV non-immune participants, 96.1% (197/205) received one or more vaccine doses and 91.0% (172/189) received two vaccine doses. Among HBV non-immune participants, 97.6 % (81/83) received one or more vaccine doses and 78.4% (58/74) received three doses. On the last-visit sample, anti-HAV IgG and anti-HBs Abs were respectively detected in 94.8% (95% CI 90.0% to 97.7%) and 79.6% (95% CI 66.5% to 89.4%) of participants with complete vaccination and in 80.0% (95% CI 51.9% to 95.7%) and 40.0% (95% CI 16.3% to 67.7%) of participants with incomplete vaccination.Vaccine acceptability against HAV and HBV infections was very high in MSM starting PrEP. Immunisation was high in participants with a full vaccination scheme. Physicians must consider PrEP visits as major opportunities to propose and complete HAV and HBV vaccination in at-risk non-immune subjects.

Trial registration: ClinicalTrials.gov NCT 01473472.

Keywords: HEPATITIS A; HEPATITIS B; Pre-Exposure Prophylaxis; VACCINATION.

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Conflict of interest statement

Competing interests: J-MM reports grants from Gilead and participated to advisory board for Gilead, Merck and ViiV for studies unrelated to this current work. GP reports grants from Gilead and Bristol Myers Squibb and personal fees (board membership) from Gilead, Bristol Myers Squibb, Boehrringer Ingelheim, Nephrotek, ViiV Healthcare, Abbvie and MSD for studies unrelated to this current work. FR reports personal fees from Gilead, Janssen, MSD, Theratechnologies and ViiV Healthcare for studies unrelated to this current work. All other authors report no potential conflicts and have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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