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Clinical Trial
. 2023 Aug 1;108(8):2244-2248.
doi: 10.3324/haematol.2022.282258.

Activity of decitabine combined with all- trans retinoic acid in oligoblastic acute myeloid leukemia: results from a randomized 2x2 phase II trial (DECIDER)

Christoph Rummelt  1 , Olga Grishina  2 , Claudia Schmoor  2 , Martina Crysandt  3 , Michael Heuser  4 , Katharina S Götze  5 , Richard F Schlenk  6 , Konstanze Döhner  7 , Helmut R Salih  8 , Gerhard Heil  9 , Carsten Müller-Tidow  10 , Wolfram Brugger  11 , Andrea Kündgen  12 , Maike De Wit  13 , Aristoteles Giagounidis  14 , Sebastian Scholl  15 , Andreas Neubauer  16 , Jürgen Krauter  17 , Gesine Bug  18 , Haifa Kathrin Al-Ali  19 , Ralph Wäsch  1 , Heiko Becker  20 , Annette M May  21 , Justus Duyster  20 , Björn Hackanson  22 , Arnold Ganser  4 , Hartmut Döhner  23 , Michael Lübbert  24
Affiliations
Clinical Trial

Activity of decitabine combined with all- trans retinoic acid in oligoblastic acute myeloid leukemia: results from a randomized 2x2 phase II trial (DECIDER)

Christoph Rummelt et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Effects of the addition of all-trans retinoic acid and valproic acid to decitabine on overall survival. (A) Overall survival (OS) according to treatment arms: A: black, B: red, C: blue, D: green. (B) OS according to treatment with decitabine plus all-trans retinoic acid (DEC + ATRA) (+/- valproic acid [VPA]) (red curves) compared to DEC (+/- VPA) (blue curves, Kaplan-Meier method). Solid curves: unadjusted; broken curves: adjustment for Eastern Cooperative Oncology Group performance status, comorbidities (hematopoietic cell transplantation index), serum lactate dehydrogenase, hemoglobin, genetic risk (ELN 2010). (C) OS according to treatment with DEC + VPA (+/- ATRA) (red curves) compared to DEC (+/- ATRA) (blue curves, Kaplan-Meier method). Solid curves: unadjusted; broken curves: Eastern Cooperative Oncology Group performance status, comorbidities (hematopoietic cell transplantation index), serum lactate dehydrogenase, hemoglobin, genetic risk (ELN 2010).
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