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. 2023 Apr;22(2):729-738.
doi: 10.1007/s10237-022-01677-z. Epub 2023 Jan 5.

Impact of cyclic bending on coronary hemodynamics

Jiaqiu Wang  1   2 , Runxin Fang  3 , Hao Wu  3 , Yuqiao Xiang  4   5 , Jessica Benitez Mendieta  4   5 , Phani Kumari Paritala  4   5 , Zhenya Fan  4 , Haveena Anbananthan  4   5 , Jorge Alberto Amaya Catano  4   5 , Owen Christopher Raffel  6   7 , Zhiyong Li  8   9   10   11
Affiliations

Impact of cyclic bending on coronary hemodynamics

Jiaqiu Wang et al. Biomech Model Mechanobiol. 2023 Apr.

Abstract

It remains unknown that the degree of bias in computational fluid dynamics results without considering coronary cyclic bending. This study aims to investigate the influence of different rates of coronary cyclic bending on coronary hemodynamics. To model coronary bending, a multi-ring-controlled fluid-structural interaction model was designed. A coronary artery was simulated with various cyclic bending rates (0.5, 0.75 and 1 s, corresponding to heart rates of 120, 80 and 60 bpm) and compared against a stable model. The simulated results show that the hemodynamic parameters of vortex Q-criterion, temporal wall shear stress (WSS), time-averaged WSS (TaWSS) and oscillatory shear index (OSI) were sensitive to the changes in cyclic rate. A higher heart rate resulted in higher magnitude and larger variance in the hemodynamic parameters. Whereas, the values and distributions of flow velocity and relative residence time (RRT) did not show significant differences between different bending periods. This study suggests that a stable coronary model is not sufficient to represent the hemodynamics in a bending coronary artery. Different heart rate conditions were found to have significant impact on the hemodynamic parameters. Thus, cyclic bending should be considered to mimic the realistic hemodynamics in future patient-specific coronary hemodynamics studies.

Keywords: Coronary cyclic bending; Fluid–structure interaction; Hemodynamics.

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References

    1. Broyd C, Davies J, Escaned J, Hughes A, Parker K (2016) Wave intensity analysis and its application to the coronary circulation. Global Cardiol Sci Practice 2015(5):64. https://doi.org/10.5339/gcsp.2015.64 - DOI
    1. Eslami P, Tran J, Jin Z, Karady J, Sotoodeh R, Lu MT, Hoffmann U, Marsden A (2020) Effect of wall elasticity on hemodynamics and wall shear stress in patient-specific simulations in the coronary arteries. J Biomech Eng 142(2):0245031–02450310. https://doi.org/10.1115/1.4043722 - DOI
    1. Fan R, Tang D, Yang C, Zheng J, Bach R, Wang L, Muccigrosso D, Billiar K, Zhu J, Ma G et al (2014) Human coronary plaque wall thickness correlated positively with flow shear stress and negatively with plaque wall stress: an ivus-based fluid-structure interaction multi-patient study. Biomed Eng Online 13(1):1–14. https://doi.org/10.1186/1475-925X-13-32 - DOI
    1. Freidoonimehr N, Chin R, Zander A, Arjomandi M (2022) A review on the effect of temporal geometric variations of the coronary arteries on the wall shear stress and pressure drop. J Biomech Eng 144(1):010801. https://doi.org/10.1115/1.4051923 - DOI
    1. Hasan M, Rubenstein DA, Yin W (2013) Effects of cyclic motion on coronary blood flow. J Biomech Eng 135(12):121002. https://doi.org/10.1115/1.4025335 - DOI

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