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. 2023 Jan 20;25(2):336-340.
doi: 10.1021/acs.orglett.2c03910. Epub 2023 Jan 5.

1,2-Diacylation of Alkynes Using Acyl Fluorides and Acylsilanes by P(III)/P(V) Catalysis

Hayato Fujimoto  1   2 , Shisato Yamamura  1 , Momoka Kusano  1 , Mamoru Tobisu  1   2
Affiliations

1,2-Diacylation of Alkynes Using Acyl Fluorides and Acylsilanes by P(III)/P(V) Catalysis

Hayato Fujimoto et al. Org Lett. .

Abstract

We report herein the phosphine-catalyzed 1,2-diacylation of alkynes using acyl fluorides and acylsilanes as acyl sources. The key to the success of the reaction is a formal oxidative addition-ligand metathesis-reductive elimination cycle based on phosphine redox catalysis, which allows for the installation of two different acyl groups into an alkyne in a regioselective manner.

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