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Comment
. 2023 Jan 4;111(1):1-2.
doi: 10.1016/j.neuron.2022.11.014.

Plaque attack: Microglia have hard feelings toward amyloid-β

Harvey Davis  1 , David Attwell  2
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Plaque attack: Microglia have hard feelings toward amyloid-β

Harvey Davis et al. Neuron. .
Free article

Abstract

Classically, microglia recognize and internalize amyloid-β (Aβ) via it binding to cell surface receptors. In this issue of Neuron, Hu et al.1 report that microglia "feel" and internalize Aβ plaques using the stiffness-sensing channel Piezo1. This could allow new approaches to treating Alzheimer's disease.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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