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Comment
. 2023 Jan 4;111(1):3-5.
doi: 10.1016/j.neuron.2022.12.008.

Breaking down the barrier to medulloblastoma treatment: Piezo2 knockout disrupts the BTB and increases vascular permeability

Samuel A Sprowls  1 , Justin D Lathia  2
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Comment

Breaking down the barrier to medulloblastoma treatment: Piezo2 knockout disrupts the BTB and increases vascular permeability

Samuel A Sprowls et al. Neuron. .
Free article

Abstract

In this issue, Chen et al.1 show that genetic knockout of Piezo2 in SOX2+ medulloblastoma cells decreased local tissue stiffness, increased drug delivery across the blood-tumor barrier, and improved survival, uncovering a mechanosensitivity-dependent mechanism of action in a mouse model of pediatric brain tumors.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity.
    Chen X, Momin A, Wanggou S, Wang X, Min HK, Dou W, Gong Z, Chan J, Dong W, Fan JJ, Xiong Y, Talipova K, Zhao H, Chen YX, Veerasammy K, Fekete A, Kumar SA, Liu H, Yang Q, Son JE, Dou Z, Hu M, Pardis P, Juraschka K, Donovan LK, Zhang J, Ramaswamy V, Selvadurai HJ, Dirks PB, Taylor MD, Wang LY, Hui CC, Abzalimov R, He Y, Sun Y, Li X, Huang X. Chen X, et al. Neuron. 2023 Jan 4;111(1):30-48.e14. doi: 10.1016/j.neuron.2022.10.007. Epub 2022 Nov 1. Neuron. 2023. PMID: 36323321

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