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Comment
. 2023 Jan 19;186(2):240-242.
doi: 10.1016/j.cell.2022.12.014. Epub 2023 Jan 4.

From ABCD to E for endothelin in resistant hypertension

George R Abraham  1 , Anthony P Davenport  2
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Comment

From ABCD to E for endothelin in resistant hypertension

George R Abraham et al. Cell. .
Free article

Abstract

The potent vasoconstrictor peptide endothelin-1 has long been recognized as a physiological regulator of vascular tone. However, pharmacological blockade of the endothelin-1 pathway has few proven indications thus far. A recent clinical trial for resistant hypertension published in The Lancet may yet herald a new era for endothelin receptor antagonists into the clinical mainstream.

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Conflict of interest statement

Declaration of interests A.P.D. is a co-investigator for the Medical Research Council Precision Medicine with Zibotentan in Microvascular Angina (PRIZE) Trial.

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