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Comment
. 2023 Jan;29(1):35-36.
doi: 10.1038/s41591-022-02123-4.

Finding antigens for TB vaccines: the good, the bad and the useless

Paul Ogongo  1 , Joel D Ernst  2
Affiliations
Comment

Finding antigens for TB vaccines: the good, the bad and the useless

Paul Ogongo et al. Nat Med. 2023 Jan.

Abstract

Prospective, longitudinal clinical studies incorporating high-throughput, single-cell analyses could identify which bacterial antigens to include in TB vaccines — and which to avoid.

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Conflict of interest statement

COI statement: The authors declare that they do not have any financial conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.. Characteristics of the T cell signature.
Antigenic peptides are generated through digestion of pathogen proteins by dendritic cells and other antigen-presenting cells (APC) and then bound to MHC (HLA in humans) class II proteins as epitope peptides. Some epitope peptide:MHC complexes are recognized by T cell antigen receptors (TCR). Signaling through TCRs, co-receptors, and cytokines secreted by APCs causes proliferation and differentiation of antigen (epitope)-specific T cells that differentiate to provide distinct phenotypes (T helper or T regulatory) and functionality (cytokine secretion and other effectors). Activated antigen-specific T cells traffic to specific tissue sites to perform their effector functions and to mature into memory T cells and acquire inhibitory coreceptor markers of maturation. Central to the process is the recognition of specific peptide:MHC complexes by clonal TCRs.
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Comment on

References

    1. Kagina BM, Abel B, Scriba TJ, Hughes EJ, Keyser A, Soares A, Gamieldien H, Sidibana M, Hatherill M, Gelderbloem S, Mahomed H, Hawkridge A, Hussey G, Kaplan G, Hanekom WA. Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guérin vaccination of newborns. Am J Respir Crit Care Med 2010;182(8):1073–9. Epub 2010/06/19. doi: 10.1164/rccm.201003-0334OC. - DOI - PMC - PubMed
    1. Tameris MD, Hatherill M, Landry BS, Scriba TJ, Snowden MA, Lockhart S, Shea JE, McClain JB, Hussey GD, Hanekom WA, Mahomed H, McShane H. Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial. Lancet 2013;381(9871):1021–8. Epub 2013/02/09. doi: 10.1016/s0140-6736(13)60177-4. - DOI - PMC - PubMed
    1. Musvosvi M Distinct specificities in the αβ T cell response to Mycobacterium tuberculosis infection: control versus disease progression. Nature Medicine 2022.
    1. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 1998;393(6685):537–44. Epub 1998/06/20. doi: 10.1038/31159. - DOI - PubMed
    1. Glanville J, Huang H, Nau A, Hatton O, Wagar LE, Rubelt F, Ji X, Han A, Krams SM, Pettus C, Haas N, Arlehamn CSL, Sette A, Boyd SD, Scriba TJ, Martinez OM, Davis MM. Identifying specificity groups in the T cell receptor repertoire. Nature 2017;547(7661):94–8. Epub 20170621. doi: 10.1038/nature22976. - DOI - PMC - PubMed

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