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. 2023 Jan 5;23(1):2.
doi: 10.1186/s12880-022-00896-1.

Clinical performance of digital breast tomosynthesis-guided vacuum-assisted biopsy: a single-institution experience in Japan

Mirai Ido  1 , Masayuki Saito  1 , Hirona Banno  1 , Yukie Ito  1 , Manami Goto  1 , Takahito Ando  1 , Junko Kousaka  1 , Yukako Mouri  1 , Kimihito Fujii  1 , Tsuneo Imai  1 , Shogo Nakano  2 , Kojiro Suzuki  3 , Kenta Murotani  4
Affiliations

Clinical performance of digital breast tomosynthesis-guided vacuum-assisted biopsy: a single-institution experience in Japan

Mirai Ido et al. BMC Med Imaging. .

Abstract

Background: The purpose of this study was to evaluate the clinical performance of Digital Breast Tomosynthesis guided vacuum-assisted biopsy (DBT-VAB) for microcalcifications in the breast.

Methods: Retrospective review of 131 mammography-guided VABs at our institution were performed. All of the targets were calcification lesion suspicious for cancer. 45 consecutive stereotactic vacuum-assisted biopsies (ST-VABs) and 86 consecutive DBT-VABs were compared. Written informed consent was obtained. Tissue sampling methods and materials were the same with both systems. Student's t-test was used to compare procedure time and the Fisher's exact test was used to compare success rate, complications, and histopathologic findings for the 2 methods.

Results: The tissue sampling success rate was 95.6% for ST-VAB (43/45) and 97.7% (84/86) for DBT-VAB. Time for positioning (10.6 ± 6.4 vs. 6.7 ± 5.3 min), time for biopsy (33.4 ± 13.1 vs. 22.5 ± 13.1 min), and overall procedure time (66.6 ± 16.6 min vs. 54.5 ± 13.0 min) were substantially shorter with DBT-VAB (P < 0.0001). There were no differences in the distribution of pathological findings between the 2 groups.

Conclusion: Depth information and stable visibility of the target provided by DBT images led to quick decisions about target coordinates and improved the clinical performance of microcalcification biopsies.

Keywords: Breast cancer; Breast microcalcifications; Digital breast tomosynthesis; Digital breast tomosynthesis–guided vacuum-assisted biopsy; Stereotactic biopsy.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
3D mammography images and tomoscout shooting of a calcified target. Thin-slice tomograms are reconstructed from one tomoscout shooting, in which 15 low-dose projections are taken with ± 7.5 degrees of turning. The target calcified lesion is identified by scrolling through the tomographic views
Fig. 2
Fig. 2
2D mammography images and targeting using stereo pair shooting. One-view mammogram providing a flat value (x and y coordinates) after stereo pair shooting. Two images of the target with ± 15 degrees of turning are used to calculate the depth of the target. (z coordinate) using triangulation
Fig. 3
Fig. 3
ST-VAB and DBT-VAB procedures
See this image and copyright information in PMC

References

    1. Gilbert FJ, Tucker L, Young KC. Digital breast tomosynthesis (DBT): a review of the evidence for use as a screening tool. Clin Radiol. 2016;71(2):141–150. doi: 10.1016/j.crad.2015.11.008. - DOI - PubMed
    1. Peppard HR, Nicholson BE, Rochman CM, Merchant JK, Mayo RC, 3rd, Harvey JA. Digital breast tomosynthesis in the diagnostic setting: indications and clinical applications. Radiographics. 2015;35(4):975–990. doi: 10.1148/rg.2015140204. - DOI - PubMed
    1. Roth RG, Maidment AD, Weinstein SP, Roth SO, Conant EF. Digital breast tomosynthesis: lessons learned from early clinical implementation. Radiographics. 2014;34(4):E89–102. doi: 10.1148/rg.344130087. - DOI - PMC - PubMed
    1. Bernardi D, Li T, Pellegrini M, Macaskill P, Valentini M, Fanto C, Ostillio L, Houssami N. Effect of integrating digital breast tomosynthesis (3D-mammography) with acquired or synthetic 2D-mammography on radiologists' true-positive and false-positive detection in a population screening trial: a descriptive study. Eur J Radiol. 2018;106:26–31. doi: 10.1016/j.ejrad.2018.07.008. - DOI - PubMed
    1. Lang K, Andersson I, Rosso A, Tingberg A, Timberg P, Zackrisson S. Performance of one-view breast tomosynthesis as a stand-alone breast cancer screening modality: results from the malmo breast tomosynthesis screening trial, a population-based study. Eur Radiol. 2016;26(1):184–190. doi: 10.1007/s00330-015-3803-3. - DOI - PMC - PubMed