[Role of Piezo1 channel in cardiovascular diseases and its research progress in traditional Chinese medicine]

Abstract

Piezo1 channel is a mechanosensitive ion channel that opens in response to shear stress, tension, torsion and a series of mechanical stimulation and turns them into biological signals. It plays an important role in vascular development, vasoconstriction and vasodilation, formation of arterial and venous valves, blood pressure regulation and red blood cell homeostasis, and thus is closely related to cardiovascular system. Recent studies have shown that traditional Chinese medicine(TCM) compounds and their active components can affect Ca~(2+) influx and endothelial cell and platelet function by mediating Piezo1 channel, and regulate thrombosis and endothelial homeostasis, thereby treating cardiovascular diseases. This study mainly reviewed the role of Piezo1 channel in cardiovascular diseases and the prevention and treatment of cardiovascular diseases based on Piezo1 channel in TCM, in order to provide effective reference for the further research of Piezo1 channel in the field of TCM.

Keywords: Piezo1; cardiovascular disease; mechanosensitive ion channel; review; traditional Chinese medicine.