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. 2021 Oct;13(4):339-342.
doi: 10.34172/mejdd.2021.244. Epub 2021 Jun 11.

Prevalence of IgE-Mediated Food Hypersensitivity to Cereals and Beans Based on Skin Prick Test in Children with Celiac Disease

Ali Jafari  1 , Somayeh Kayvanloo  1 , Nasrin Moazzen  1 , Nasrinsadat Motevalli Haghi  1 , Nilufar Sedghi  1 , Maryam Khoshkhui  2 , Hamid Ahanchian  1
Affiliations

Prevalence of IgE-Mediated Food Hypersensitivity to Cereals and Beans Based on Skin Prick Test in Children with Celiac Disease

Ali Jafari et al. Middle East J Dig Dis. 2021 Oct.

Abstract

BACKGROUND Celiac disease is a non-IgE mediated food allergy, which can cause extensive villus atrophy. Because of increased food allergen absorption, there are elevated IgA and IgG antibodies in these patients, so there is a concern about IgE antibody production against wheat and other cereals. METHODS In this study, we evaluated IgE-mediated hypersensitivity to wheat, rice, and other cereals in children with celiac disease. RESULTS 22 patients (50%) had at least one positive skin prick test to food allergens. The most frequent food allergen was peanut (31.8%), followed by wheat (18.2%), corn (9.1%), and rice (4.5%). The results revealed no significant correlation between age, sex, and the results of the skin prick test (p >0.05). The correlation between diagnosis time of celiac disease and results of skin prick test was also not significant statistically (p >0.05). CONCLUSION Because of the high prevalence of IgE mediated hypersensitivity to cereals and beans in children with celiac disease, a skin prick test might be considered in these patients, especially in refractory cases.

Keywords: Celiac disease; Food allergy; IgE mediated hypersensitivity; Skin prick test.

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Conflict of interest statement

CONFLICT OF INTEREST The authors declare no conflict of interest related to this work

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