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Review
. 2023 Jan;87(1):3-8.

A comprehensive review of genomic perspectives of canine diseases as a model to study human disorders

Bhawanpreet Kaur  1 , Jaswinder Kaur  1 , Neeraj Kashyap  1 , Jaspreet Singh Arora  1 , Chandra Sekhar Mukhopadhyay  1
Affiliations
Review

A comprehensive review of genomic perspectives of canine diseases as a model to study human disorders

Bhawanpreet Kaur et al. Can J Vet Res. 2023 Jan.

Abstract
in English, French

The domestic dog has been given considerable attention as a system for investigating the genetics of human diseases. Population diversity and breed structure are unique features that make dogs particularly amenable to genetic studies. Dogs show distinguished features of breed-specific homogeneity, which is associated with striking interbreed heterogeneity. This review discusses the significance of studying the genetic maps, genome-wide association studies (GWAS), and usefulness of this species as an animal model. Most canine genetic disorders are similar to those of humans, including inherited, psychiatric, and genetic disorders. In addition to revealing new candidate genes, canine models allow access to experimental resources, such as cells, tissues, and even live animals, for research and intervention purposes.

Le chien domestique a reçu une attention considérable en tant que système d’investigation de la génétique des maladies humaines. La diversité de la population et la structure de la race sont des caractéristiques uniques qui rendent les chiens particulièrement propices aux études génétiques. Les chiens présentent des caractéristiques distinctes d’homogénéité spécifique à la race, qui est associée à une hétérogénéité interraciale frappante. Cette revue traite de l’importance de l’étude des cartes génétiques, des études d’association à l’échelle du génome (GWAS) et de l’utilité de cette espèce en tant que modèle animal. La plupart des troubles génétiques canins sont similaires à ceux des humains, y compris les troubles héréditaires, psychiatriques et génétiques. En plus de révéler de nouveaux gènes candidats, les modèles canins permettent d’accéder à des ressources expérimentales, telles que des cellules, des tissus et même des animaux vivants, à des fins de recherche et d’intervention.(Traduit par Docteur Serge Messier).

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