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Review
. 2022 Nov 28;13(15):3674-3686.
doi: 10.7150/jca.78090. eCollection 2022.

Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression

Zeyu Wei  1   2   3 , Yijia Shi  1   2   3 , Changning Xue  1   3   4 , Mengna Li  1   3   4 , Jianxia Wei  1   3   4 , Guiyuan Li  1   3   4 , Wei Xiong  1   3   4 , Ming Zhou  1   3   4
Affiliations
Review

Understanding the Dual Roles of CircHIPK3 in Tumorigenesis and Tumor Progression

Zeyu Wei et al. J Cancer. .

Abstract

CircHIPK3 is a type of endogenous circular RNA, which contains a covalently closed circular structure and cannot encode protein or polypeptide. CircHIPK3 is unusually expressed in varieties of tumors and plays dual roles of tumor promotion or tumor inhibition in tumorigenesis and development of tumors by serving as the sponge for miRNA in multiple tumors. Here, we reviewed the differential expression, the dual functions, the regulation mechanism, and the network in a variety of tumors as well as the potential value for the diagnosis and treatment of tumors, which are of great significance for our comprehensive understanding of the roles and mechanisms of circHIPK3 in tumors.

Keywords: circHIPK3; differential expression; dual roles; regulation mechanism; tumorigenesis.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Generation and upstream regulation mechanism of circHIPK3. CircHIPK3, a sort of circRNAs which is derived from the exon 2 of HIPK3 gene, locates in the chromosome 11p13. C-Myb was confirmed as a transcription factor of circHIPK3, which could bind the promoter region and promote the transcription activity and expression of circHIPK3 in CRC. In addition, HIF-2α was found to positively regulate the expression of circHIPK3 in GC under a hypoxic microenvironment, indicating that circHIPK3 is a potential transcription regulation target of HIF-2α.
Figure 2
Figure 2
Downstream regulatory network of circHIPK3. CircHIPK3 is frequently abnormally expressed in some types of cancers, playing an oncogenic role in most cancers, such as lung cancer, oral squamous cell cancer, gastric cancer, colorectal cancer, and so on. CircHIPK3 also plays an anti-tumor role in bladder cancer. CircHIPK3 can act as a miRNA sponge to regulate the expression of mRNA at the post-transcriptional level, making contributions to the functions of promoting or restraining cancers. CircHIPK3 can also regulate the expression of RBP through ceRNA mechanism and compete with target mRNA to modulate gene expression at transcriptional and post-transcriptional levels.
See this image and copyright information in PMC

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