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. 2023 Jul;89(7):1978-1991.
doi: 10.1111/bcp.15657. Epub 2023 Jan 25.

Optimizing adherence to allopurinol for gout: patients' perspectives

Jane C J Spragg  1 , Toni J F Michael  2 , Parisa Aslani  1 , Matthew J Coleshill  3   4 , Jian S Chan  1   4 , Richard O Day  5   6 , Sophie L Stocker  1   5   6
Affiliations
Free article

Optimizing adherence to allopurinol for gout: patients' perspectives

Jane C J Spragg et al. Br J Clin Pharmacol. 2023 Jul.
Free article

Abstract

Aims: Poor adherence to allopurinol among people with gout contributes to suboptimal gout management. This study sought to understand the facilitators and barriers to allopurinol adherence across the three stages of medication adherence, and patient perspectives on strategies to improve adherence, including self-monitoring urate concentration.

Methods: Semi-structured interviews were conducted with 26 people with gout, previously or currently taking allopurinol. De-identified verbatim transcripts were thematically analysed using an inductive and deductive approach.

Results: Facilitators of adherence during allopurinol initiation were motivation to prevent gout flares and trust in the advice of their healthcare professionals (HCPs). Reluctance to commence long-term medication was a barrier to allopurinol initiation. Believing in the effectiveness and necessity of allopurinol and reminder systems were facilitators of implementation. Barriers to implementation included forgetfulness, gout flares and limited feedback on allopurinol's effectiveness. Patients discontinued therapy when allopurinol was perceived as ineffective or unnecessary. Discontinuation coincided with patients experiencing gout flares while adhering to allopurinol and receiving suboptimal advice about gout management. Patients identified receiving accurate advice from HCPs and regular urate monitoring for feedback on allopurinol's effectiveness as potential strategies to improve adherence. Perceived benefits of self-monitoring urate as a strategy to promote adherence included the ability to self-manage gout and make informed decisions about allopurinol therapy with their HCP.

Conclusion: Patient perceptions of the effectiveness and necessity of allopurinol influenced intentional adherence during medication initiation, implementation and discontinuation. Strategies that inform patients of their urate control and provide accurate medical advice have the potential to improve adherence to allopurinol.

Keywords: adherence; gout; intervention; patient perspective; qualitative research; urate-lowering therapy.

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