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. 2023 Feb 1;48(2):e99-e100.
doi: 10.1097/RLU.0000000000004382. Epub 2022 Sep 6.

Lhermitte-Duclos Disease Related With Cowden Syndrome Mimicking Metastatic Lung Cancer on FDG PET/CT

Selin Kesim  1 , Salih Ozguven, Kevser Oksuzoglu, Tanju Yusuf Erdil
Affiliations

Lhermitte-Duclos Disease Related With Cowden Syndrome Mimicking Metastatic Lung Cancer on FDG PET/CT

Selin Kesim et al. Clin Nucl Med. .

Abstract

Cowden syndrome is characterized by multiple hamartomatous and neoplastic lesions including Lhermitte-Duclos disease, which is the main criterion for the diagnosis. Herein, we presented a patient with suspected metastatic disease referred to PET/CT, which showed mildly hypermetabolic multinodular thyroid goiter, multiple hamartomatous pulmonary, and breast nodules. Also, intense hypermetabolism was noted on the cerebellar tumor lesion. Lhermitte-Duclos disease was diagnosed based on the characteristic MRI findings, and she was followed up with a diagnosis of Cowden syndrome. Our case indicates that Cowden syndrome should be included as a differential diagnosis of abnormal FDG uptake in the multiple systemic hamartomatous tumors.

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Conflict of interest statement

Conflicts of interest and sources of funding: none declared.

References

    1. Piekarski E, Pyatigorskaya N, Dormont D, et al. Increased 18 F-FDG uptake in Lhermitte-Duclos disease with Cowden syndrome revealed by PET-MRI. Clin Nucl Med . 2018;43:355–356.
    1. Hayasaka K, Nihashi T, Takebayashi S, et al. FDG PET in Lhermitte-Duclos disease. Clin Nucl Med . 2008;33:52–54.
    1. Goto Y, Hashimoto N, Okita Y, et al. A surgically treated case of Lhermitte-Duclos disease with a precise natural history and high uptake of FDG on PET. J Neurooncol . 2010;97:445–450.
    1. Nakagawa T, Maeda M, Kato M, et al. A case of Lhermitte-Duclos disease presenting high FDG uptake on FDG-PET/CT. J Neurooncol . 2007;84:185–188.
    1. Vantomme N, Van Calenbergh F, Goffin J, et al. Lhermitte-Duclos disease is a clinical manifestation of Cowden’s syndrome. Surg Neurol . 2001;56:201–204 discussion 204-205.

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