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Comment
. 2023 Jan 5;186(1):10-11.
doi: 10.1016/j.cell.2022.11.025.

Sweet splicing

Maria Carmo-Fonseca  1
Affiliations
Free article
Comment

Sweet splicing

Maria Carmo-Fonseca. Cell. .
Free article

Abstract

Glucose is the main source of energy for cells. In this issue of Cell, a study now shows that glucose has additional non-energetic functions, acting as a biomolecular cue that regulates alternative splicing during epidermal differentiation. As keratinocytes differentiate, glucose associates with RNA-binding protein DDX21 and modulates its interaction properties, which modifies splicing decisions.

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Conflict of interest statement

Declaration of interests Maria Carmo-Fonseca is a founder of GenoMed-diagnosticos de medicina molecular, sociedade anónima (SA) and a member of its scientific advisory board.

Comment on

  • Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation.
    Miao W, Porter DF, Lopez-Pajares V, Siprashvili Z, Meyers RM, Bai Y, Nguyen DT, Ko LA, Zarnegar BJ, Ferguson ID, Mills MM, Jilly-Rehak CE, Wu CG, Yang YY, Meyers JM, Hong AW, Reynolds DL, Ramanathan M, Tao S, Jiang S, Flynn RA, Wang Y, Nolan GP, Khavari PA. Miao W, et al. Cell. 2023 Jan 5;186(1):80-97.e26. doi: 10.1016/j.cell.2022.12.004. Cell. 2023. PMID: 36608661 Free PMC article.

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