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Comment
. 2023 Jan 5;30(1):1-2.
doi: 10.1016/j.stem.2022.12.004.

Regrowing the heart, one TREE at a time

Jeffrey D Steimle  1 , James F Martin  2
Affiliations
Free article
Comment

Regrowing the heart, one TREE at a time

Jeffrey D Steimle et al. Cell Stem Cell. .
Free article

Abstract

While many animals can completely repair injured tissues, the mammalian heart possesses limited regenerative capabilities. Yan and Cigliola et al. show that AAV-mediated, zebrafish-derived tissue regeneration enhancer elements (TREEs) can direct pro-regenerative gene expression in injured cardiac tissue of mice and pigs that turn off following repair.

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Conflict of interest statement

Declaration of interests J.F.M. is a co-founder of and owns shares in Yap Therapeutics. J.F.M. holds the following patents: US2020/0,206,327 “Hippo Pathway Deficiency Reverses Systolic Heart Failure Post-Infarction” and US2014/069,349 “Hippo and Dystrophin Complex Signaling in Cardiomyocyte Renewal.”

Comment on

  • An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.
    Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, Kang J, Goldman JA, Baht GS, Karra R, Williams AR, Bowles DE, Asokan A, Tzahor E, Gersbach CA, Molkentin JD, Bursac N, Black BL, Poss KD. Yan R, et al. Cell Stem Cell. 2023 Jan 5;30(1):96-111.e6. doi: 10.1016/j.stem.2022.11.012. Epub 2022 Dec 13. Cell Stem Cell. 2023. PMID: 36516837 Free PMC article.

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