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. 2023 Jan 5;30(1):3-4.
doi: 10.1016/j.stem.2022.12.011.

New readers and writers of RNA modifications unique to leukemia stem cells

Takeshi Fujino  1 , Omar Abdel-Wahab  2
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New readers and writers of RNA modifications unique to leukemia stem cells

Takeshi Fujino et al. Cell Stem Cell. .
Free article

Abstract

Chemical modifications of RNA are regulated by a series of readers, writers, and erasers that dictate gene expression. Two new studies in Cell Stem Cell1,2identify roles for the N6-methyladenosine (m6A) methyltransferase METTL16 and the m6A reader IGF2BP2 in leukemia-initiating cells, illuminating exciting new therapeutic targets for leukemia.

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