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. 2023 Jan 6;11(1):3.
doi: 10.1186/s40478-022-01490-w.

Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome

Léa Guerrini-Rousseau #  1   2 , Arnault Tauziède-Espariat #  3   4 , David Castel  2 , Etienne Rouleau  5 , Philipp Sievers  6   7 , Raphaël Saffroy  8 , Kévin Beccaria  9 , Thomas Blauwblomme  9 , Lauren Hasty  10 , Franck Bourdeaut  11 , Jacques Grill  1   2 , Pascale Varlet  10   12 , Marie-Anne Debily  2   13
Affiliations

Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome

Léa Guerrini-Rousseau et al. Acta Neuropathol Commun. .
No abstract available

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Conflict of interest statement

The authors declare that they have no conflicts of interest directly related to the topic of this article.

Figures

Fig. 1
Fig. 1
t-Distributed stochastic neighbor embedding (t-SNE) analysis of DNA methylation profiles of the investigated tumors alongside selected reference samples. Reference DNA methylation classes: high-grade astrocytoma with piloid features (ANA PA); diffuse high-grade glioma, H3.3 G34 mutant (DHG H3 G34); diffuse midline glioma H3 K27M mutant (DMG H3 K27); pediatric glioblastoma, IDH wildtype, subclass MYCN (GB pedMYCN); pediatric glioblastoma, IDH wildtype, subclass not otherwise specified sutbype A (GB pedNOS A); pediatric glioblastoma, IDH wildtype, subclass not otherwise specified sutbype B (GB pedNOS B); pediatric glioblastoma, IDH wildtype, subclass RTK1a (GB pedRTK1a); pediatric glioblastoma, IDH wildtype, subclass RTK1b (GB pedRTK1b); pediatric glioblastoma, IDH wildtype, subclass RTK1c (GB pedRTK1c); pediatric glioblastoma, IDH wildtype, subclass RTK2a (GB pedRTK2a); pediatric glioblastoma, IDH wildtype, subclass RTK2b (GB pedRTK2b); infant-type hemispheric glioma (IHG); hemispheric pilocytic astrocytoma (PA CORT); infratentorial pilocytic astrocytoma (PA INF); midline pilocytic astrocytoma (PA MID); pleomorphic xanthoastrocytoma (PXA)
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