Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Apr 28;69(5):438-441.
doi: 10.1093/clinchem/hvac177.

Foreseeing Alcohol-Associated Liver Disease through Proteomic Biomarkers

P Vineeth Daniel  1 , Harmeet Malhi  1
Affiliations
Comment

Foreseeing Alcohol-Associated Liver Disease through Proteomic Biomarkers

P Vineeth Daniel et al. Clin Chem. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Authors’ Disclosures or Potential Conflicts of Interest: Upon manuscript submission, all authors completed the author disclosure form. The authors declare that no conflict of interest exists.

Figures

Fig. 1.
Fig. 1.
Integrative liver: plasma proteomics for AALD. This graphic summarizes the steps involved in the development of a biomarker panel for AALD integrating the liver and plasma proteome. In the liver, 5515 proteins were detected and 536 proteins were detected in plasma. Liver-plasma pairwise correlation identified 46 co-dysregulated proteins that were modeled via a machine-learning approach to predict significant fibrosis (stage 2, F2), inflammatory activity (numerical sum of ballooning and inflammation according to the NAFLD Activity Score, I2), or steatosis (S1) (3). Abbreviations: C7, complement component 7; CFH, complement factor H; QSOX1, quiescin sulfhydryl oxidase 1; LGALS3BP, lectin galactoside-binding soluble 3 binding protein; TGFB1, transforming growth factor-beta 1; ASAP1, ArfGAP (ADP-ribosylation factor-directed GTPase-activating protein 1) with SH3 domain, ankyrin repeat- and PH domain 1; F2, coagulation factor II, thrombin; TTR, transthyretin; APOF, apolipoprotein F; ORM1, orosomucoid 1; ALDOB, aldolase B; SERPINC1, serpin family C member 1; CLEC3B, C-type lectin domain family 3 member B; FBLN1, fibulin 1; LBP, lipopolysaccharide binding protein; ITIH4, inter-alpha-trypsin inhibitor heavy chain 4; PRG4, proteoglycan 4; ATRN, attractin; SELENOP, selenoprotein P; SERPINF1, serpin family F member 1; PEPD, peptidase D; AFM, afamin.
See this image and copyright information in PMC

Comment on

  • Noninvasive proteomic biomarkers for alcohol-related liver disease.
    Niu L, Thiele M, Geyer PE, Rasmussen DN, Webel HE, Santos A, Gupta R, Meier F, Strauss M, Kjaergaard M, Lindvig K, Jacobsen S, Rasmussen S, Hansen T, Krag A, Mann M. Niu L, et al. Nat Med. 2022 Jun;28(6):1277-1287. doi: 10.1038/s41591-022-01850-y. Epub 2022 Jun 2. Nat Med. 2022. PMID: 35654907 Free PMC article.

References

    1. Cheemerla S, Balakrishnan M. Global epidemiology of chronic liver disease. Clin Liver Dis (Hoboken) 2021;17: 365–70. - PMC - PubMed
    1. Julien J, Ayer T, Bethea ED, Tapper EB, Chhatwal J. Projected prevalence and mortality associated with alcohol-related liver disease in the USA, 2019–40: a modelling study. Lancet Public Health 2020;5:e316–23. - PubMed
    1. Niu L, Thiele M, Geyer PE, Rasmussen DN, Webel HE, Santos A, et al. Noninvasive proteomic biomarkers for alcohol-related liver disease. Nat Med 2022;28:1277–87. - PMC - PubMed
    1. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41: 1313–21. - PubMed
    1. Krasny L, Huang PH. Data-independent acquisition mass spectrometry (DIA-MS) for proteomic applications in oncology. Mol Omics 2021;17:29–42. - PubMed

Publication types