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Case Reports
. 2023 Jan 7;168(2):45.
doi: 10.1007/s00705-022-05685-3.

Sequence analysis of a feline- and porcine-origin G3P[9] rotavirus A strain in a child with acute gastroenteritis in Japan

Yuya Fukuda  1   2 , Kaoru Araki  3 , Megumi Hara  4 , Yuji Yamashita  5 , Shuhei Adachi  2 , Saho Honjo  2 , Atsuo Togashi  2 , Satoshi Hirakawa  2 , Shinobu Fukumura  2 , Masaki Yamamoto  2 , Takeshi Tsugawa  6
Affiliations
Case Reports

Sequence analysis of a feline- and porcine-origin G3P[9] rotavirus A strain in a child with acute gastroenteritis in Japan

Yuya Fukuda et al. Arch Virol. .

Abstract

We isolated the rare G3P[9] rotavirus strain RVA/Human-wt/JPN/R11-035/2015/G3P[9] from a 2-year-old girl presenting with vomiting and diarrhea who had daily contact with cats in Japan, 2015. Full-genome analysis revealed that the R11-035 strain had an AU-1-like genetic constellation, except for the NSP3 (T) gene: G3-P[9]-I3-R3-C3-M3-A3-N3-T1-E3-H6. Phylogenetic analysis showed that strain R11-035 is closely related to human/feline-like human strains, and only the NSP3 (T1) gene was clustered together with Taiwanese porcine strains. We postulate that the R11-035 strain was directly transmitted from a cat to the patient and acquired its NSP3 gene through intergenotype reassortment with porcine strains before being transmitted to humans.

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