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Comment
. 2023 Jan;55(1):10-11.
doi: 10.1038/s41588-022-01244-3.

Spatial atlas reveals insight into lung immunity

No authors listed
Comment

Spatial atlas reveals insight into lung immunity

No authors listed. Nat Genet. 2023 Jan.
No abstract available

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Comment on

  • A spatially resolved atlas of the human lung characterizes a gland-associated immune niche.
    Madissoon E, Oliver AJ, Kleshchevnikov V, Wilbrey-Clark A, Polanski K, Richoz N, Ribeiro Orsi A, Mamanova L, Bolt L, Elmentaite R, Pett JP, Huang N, Xu C, He P, Dabrowska M, Pritchard S, Tuck L, Prigmore E, Perera S, Knights A, Oszlanczi A, Hunter A, Vieira SF, Patel M, Lindeboom RGH, Campos LS, Matsuo K, Nakayama T, Yoshida M, Worlock KB, Nikolić MZ, Georgakopoulos N, Mahbubani KT, Saeb-Parsy K, Bayraktar OA, Clatworthy MR, Stegle O, Kumasaka N, Teichmann SA, Meyer KB. Madissoon E, et al. Nat Genet. 2023 Jan;55(1):66-77. doi: 10.1038/s41588-022-01243-4. Epub 2022 Dec 21. Nat Genet. 2023. PMID: 36543915 Free PMC article.

References

    1. Schiller, H. B. et al. The human lung cell atlas: a high resolution reference map of the human lung in health and disease. Am. J. Respir. Cell Mol. Biol. 61, 31–41 (2019). A review article that provides a roadmap for the human lung cell atlas, including the rationale, approach and expected impact. - DOI
    1. Vieira Braga, F. A. A cellular census of human lungs identifies novel cell states in health and in asthma. Nat. Med. 25, 1153–1163 (2019). An early single-cell sequencing study of the lung and airways of healthy individuals and those with asthma. - DOI
    1. Hewitt, R. J. & Lloyd, C. M. Regulation of immune responses by the airway epithelial cell landscape. Nat. Rev. Immunol. 21, 347–362 (2021). This paper reviews how transcriptomic analyses have advanced our understanding of epithelial and immune cell regulation in the airways. - DOI
    1. Kleshchevnikov, V. et al. Cell2location maps fine-grained cell types in spatial transcriptomics. Nat. Biotechnol. 40, 661–671 (2022). This paper presents cell2location, a method for integrating single-cell and spatial transcriptomic data in order to resolve the spatial contexts of cells. - DOI
    1. Sikkema, L. et al. An integrated cell atlas of the human lung in health and disease. Preprint at bioRxiv https://doi.org/10.1101/2022.03.10.483747 (2021). This preprint presents the integrated human lung cell atlas, which comprises more than 400 donor lungs and airways profiled by single-cell transcriptomics, including those presented here.

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