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Comment
. 2023 Feb;24(2):216-217.
doi: 10.1038/s41590-022-01400-1.

Lipid homeostasis mediated by cholesterol synthesis supports B cell responses to vaccination

No authors listed
Comment

Lipid homeostasis mediated by cholesterol synthesis supports B cell responses to vaccination

No authors listed. Nat Immunol. 2023 Feb.
No abstract available

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Comment on

  • SREBP signaling is essential for effective B cell responses.
    Luo W, Adamska JZ, Li C, Verma R, Liu Q, Hagan T, Wimmers F, Gupta S, Feng Y, Jiang W, Zhou J, Valore E, Wang Y, Trisal M, Subramaniam S, Osborne TF, Pulendran B. Luo W, et al. Nat Immunol. 2023 Feb;24(2):337-348. doi: 10.1038/s41590-022-01376-y. Epub 2022 Dec 28. Nat Immunol. 2023. PMID: 36577930 Free PMC article.

References

    1. Li, S. et al. Metabolic phenotypes of response to vaccination in humans. Cell 169, 862–877 (2017). This paper reports that SREBP signaling is a key modulator of antibody and follicular T cell responses. - DOI
    1. Horton, J. D., Goldstein, J. L. & Brown, M. S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109, 1125–1131 (2002). A review article discussing SREBP signaling in lipid metabolism. - DOI
    1. Kidani, Y. et al. Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat. Immunol. 14, 489–499 (2013). This paper reports a crucial role of SREBP signaling in CD8+ T cell activation. - DOI
    1. Black, S., Nicolay, U., Del Giudice, G. & Rappuoli, R. Influence of statins on influenza vaccine response in elderly individuals. J. Infect. Dis. 213, 1224–1228 (2016). This paper reports that older individuals who receive statin drugs have reduced antibody responses to influenza vaccines. - DOI
    1. Omer, S. B. et al. Impact of statins on influenza vaccine effectiveness against medically attended acute respiratory illness. J. Infect. Dis. 213, 1216–1223 (2016). This paper reports that influenza vaccines may provide reduced protection against severe illness in people who take statins. - DOI

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