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. 2023 Jan 7;408(1):12.
doi: 10.1007/s00423-023-02753-3.

Seven centimeters as an optimal cutoff value for prognosis stratification in large monofocal hepatocellular carcinoma

Yi-Hao Yen  1 , Wei-Feng Li  2 , Kwong-Ming Kee  3 , Chih-Chi Wang  4 , Yu-Fan Cheng  5 , Sheng-Nan Lu  3 , Chao-Hung Hung  3 , Yueh-Wei Liu  2 , Tsung-Hui Hu  3
Affiliations

Seven centimeters as an optimal cutoff value for prognosis stratification in large monofocal hepatocellular carcinoma

Yi-Hao Yen et al. Langenbecks Arch Surg. .

Erratum in

Abstract

Purpose: Barcelona Clinic Liver Cancer (BCLC) guidelines designate monofocal hepatocellular carcinoma (HCC) > 2 cm as BCLC A, and large monofocal HCC is defined at > 5 cm. We aimed to evaluate the optimal cutoff value for large monofocal HCC based on prognosis stratification.

Methods: From 2011 to 2018, 3055 patients with newly diagnosed HCC, who were managed in our institution, including 868 patients with monofocal HCC > 2 cm and 330 patients with BCLC B, were enrolled in this retrospective study.

Results: Monofocal HCC > 5 cm patients had worse overall survival (OS) than monofocal HCC 2-5 cm patients (5-year OS: 54% vs. 57%; p = 0.047), confirmed by multivariate analysis (hazard ratio (HR): 1.492, 95% confidence interval (CI): 1.055-2.110; p = 0.024). Monofocal HCC > 5 cm patients had better OS than BCLC B HCC patients (5-year OS: 54% vs. 25%; p < 0.001), confirmed by multivariate analysis (HR: 0.670, 95% CI: 0.481-0.934; p = 0.018). Using 7 cm as the monofocal HCC cutoff value resulted in worse OS than monofocal HCC 2-7 cm (5-year OS: 50% vs. 57%; p = 0.02), confirmed by multivariate analysis (HR: 1.625, 95% CI: 1.039-2.540; p = 0.033). Monofocal HCC > 7 cm patients had better OS than BCLC B patients (p = 0.006). However, no significant difference was identified in the multivariate analysis (HR: 0.726; 95% CI: 0.473-1.115; p = 0.144).

Conclusions: The prognosis of monofocal HCC > 7 cm was similar to that of BCLC B, indicating that 7 cm represents an optimal cutoff value for prognosis stratification in large monofocal HCC.

Keywords: Barcelona Clinic Liver Cancer; Hepatocellular carcinoma; Liver resection.

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