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Comment
. 2023 Feb 14;44(7):624-625.
doi: 10.1093/eurheartj/ehac638.

Lipoprotein(a) and progression of aortic valve calcification: a case of collider bias?

Michael G Levin  1 , Scott M Damrauer  1
Affiliations
Comment

Lipoprotein(a) and progression of aortic valve calcification: a case of collider bias?

Michael G Levin et al. Eur Heart J. .
No abstract available

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Conflict of interest statement

Conflict of interest: None declared.

Figures

Figure 1
Figure 1
Directed acyclic graph of collider bias in the association of lipoprotein(a) with aortic valve calcification progression. Stratifying on baseline aortic valve calcification induces an indirect path (red line) between lipoprotein(a) and other independent risk factors or confounding variables for aortic valve calcification. This ‘collision’ may lead to spurious, absent, or biased associations when attempting to estimate the effect of lipoprotein(a) on aortic valve calcification progression.
See this image and copyright information in PMC

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References

    1. Kaiser Y, van der Toorn JE, Singh SS, Zheng KH, Kavousi M, Sijbrands EJG, et al. . Lipoprotein(a) is associated with the onset but not the progression of aortic valve calcification. Eur Heart J 2022;43:3960–3967. 10.1093/eurheartj/ehac377 - DOI - PMC - PubMed
    1. Dahabreh IJ, Kent DM. Index event bias: an explanation for the paradoxes of recurrence risk research. JAMA 2011;305:822–823. 10.1001/jama.2011.163 - DOI - PMC - PubMed
    1. Rich JD, Cannon CP, Murphy SA, Qin J, Giugliano RP, Braunwald E. Prior aspirin use and outcomes in acute coronary syndromes. J Am Coll Cardiol 2010;56:1376–1385. 10.1016/j.jacc.2010.06.028 - DOI - PubMed
    1. Baglin T. Unraveling the thrombophilia paradox: from hypercoagulability to the prothrombotic state. J Thromb Haemost 2010;8:228–233. 10.1111/j.1538-7836.2009.03702.x - DOI - PubMed
    1. Mitchell RE, Hartley A, Walker VM, Gkatzionis A, Yarmolinsky J, Bell JA, et al. . Strategies to investigate and mitigate collider bias in genetic and Mendelian randomization studies of disease progression. medRxiv, 10.1101/2022.04.22.22274166, 22 April 2022, preprint: not peer reviewed. - DOI - PMC - PubMed

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