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. 2022 Dec 29;13(1):142.
doi: 10.3390/ani13010142.

Investigation of the Efficacy of Pyrantel Pamoate, Mebendazole, Albendazole, and Ivermectin against Baylisascaris schroederi in Captive Giant Pandas

Yaxian Lu  1 , Linhua Deng  2 , Zhiwei Peng  1 , Mengchao Zhou  1 , Chengdong Wang  2 , Lei Han  1 , Shan Huang  2 , Ming Wei  2 , Rongping Wei  2 , Lihong Tian  1 , Desheng Li  2 , Zhijun Hou  1
Affiliations

Investigation of the Efficacy of Pyrantel Pamoate, Mebendazole, Albendazole, and Ivermectin against Baylisascaris schroederi in Captive Giant Pandas

Yaxian Lu et al. Animals (Basel). .

Abstract

Baylisascaris schroederi is one of the main health risks threatening both wild and captive giant pandas. The administration of anthelmintics is a common method to effectively control B. schroederi infection, but there is a notable risk of anthelmintic resistance (AR) after long-term, constant use of anthelmintics. Four anthelmintics-pyrantel pamoate (PYR), mebendazole (MBZ), albendazole (ABZ), and ivermectin (IVM)-were each administered separately at intervals of 2 months to 22 enrolled giant pandas. The fecal egg count reduction (FECR) proportions were calculated by both the Markov chain Monte Carlo (MCMC) Bayesian mathematical model and the arithmetic mean. AR was assessed based on the criteria recommended by the World Association for the Advancement of Veterinary Parasitology (WAAVP). The estimated prevalence of B. schroederi infection was 34.1%. After treatment with PYR, MBZ, ABZ, and IVM, it was determined that MBZ, ABZ, and IVM were efficacious against B. schroederi, while nematodes were suspected to be resistant to PYR according to the fecal egg count reduction (FECR) proportions.

Keywords: Ailuropoda melanoleuca; FECRT; anthelmintic administration; anthelmintic resistance.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Infection rate, mean EPG, and number of adult worms.
Figure 2
Figure 2
Mean number of worms expelled by different sexes of giant pandas after administration of four anthelmintics.
Figure 3
Figure 3
Sex ratio of expelled worms.
See this image and copyright information in PMC

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