Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Dec 28;15(1):195.
doi: 10.3390/cancers15010195.

Quality of Life Considerations in Endoscopic Endonasal Management of Anterior Cranial Base Tumors

Anirudh Saraswathula  1 , Jose L Porras  2 , Debraj Mukherjee  2 , Nicholas R Rowan  1   2
Affiliations
Review

Quality of Life Considerations in Endoscopic Endonasal Management of Anterior Cranial Base Tumors

Anirudh Saraswathula et al. Cancers (Basel). .

Abstract

Considering quality of life (QOL) is critical when discussing treatment options for patients undergoing endoscopic endonasal skull base surgery (EESBS) for cancers at the base of the skull. Several questionnaires have been developed and validated in the last 20 years to explore QOL in this patient population, including the Anterior Skull Base Questionnaire, Skull Base Inventory, EESBS Questionnaire, and the Sino-Nasal Outcome Test for Neurosurgery. The Sino-Nasal Outcomes Test-22 and Anterior Skull Base Nasal Inventory-12 are other tools that have been used to measure sinonasal QOL in anterior cranial base surgery. In addition to pathology-related perturbations in QOL endoscopic surgical options (transsellar approaches, anterior cranial base surgery, and various reconstructive techniques) all have unique morbidities and QOL implications that should be considered. Finally, we look ahead to new and emerging techniques and tools aimed to help preserve and improve QOL for patients with anterior cranial base malignancies.

Keywords: cranial base malignancies; endoscopic endonasal skull base surgery; quality of life; rhinology; skull base.

PubMed Disclaimer

Conflict of interest statement

There are no relevant conflicts of interest.

Figures

Figure 1
Figure 1
Major opportunities for future work in quality-of-life considerations for patients with anterior cranial base malignancies.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Rutland J.W., Gill C.M., Ladner T., Goldrich D., Villavisanis D.F., Devarajan A., Pai A., Banihashemi A., Miles B.A., Sharma S., et al. Surgical Outcomes in Patients with Endoscopic versus Transcranial Approach for Skull Base Malignancies: A 10-Year Institutional Experience. Br. J. Neurosurg. 2022;36:79–85. doi: 10.1080/02688697.2020.1779659. - DOI - PubMed
    1. Lenze N.R., Quinsey C., Sasaki-Adams D., Ewend M.G., Thorp B.D., Ebert C.S., Zanation A.M. Comparative Outcomes by Surgical Approach in Patients with Malignant Sinonasal Disease. J. Neurol. Surg. Part B Skull Base. 2022;83:e353–e359. doi: 10.1055/s-0041-1729978. - DOI - PMC - PubMed
    1. Farquhar D., Kim L., Worrall D., Chiu A., Lee J.Y.K., Khalili S., Grady S., O’Malley B.W., Kennedy D.W., Newman J.G., et al. Propensity Score Analysis of Endoscopic and Open Approaches to Malignant Paranasal and Anterior Skull Base Tumor Outcomes. Laryngoscope. 2016;126:1724–1729. doi: 10.1002/lary.25885. - DOI - PubMed
    1. Barinsky G.L., Azmy M.C., Kilic S., Grube J.G., Baredes S., Hsueh W.D., Eloy J.A. Comparison of Open and Endoscopic Approaches in the Resection of Esthesioneuroblastoma. Ann. Otol. Rhinol. Laryngol. 2021;130:136–141. doi: 10.1177/0003489420939582. - DOI - PubMed
    1. Rowan N.R., Mukherjee D. Quality of Life Outcomes and Approach-Specific Morbidities in Endoscopic Endonasal Skull Base Surgery. Curr. Otorhinolaryngol. Rep. 2020;8:160–169. doi: 10.1007/s40136-020-00286-7. - DOI

LinkOut - more resources