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. 2022 Dec 31;20(1):787.
doi: 10.3390/ijerph20010787.

The Triglycerides and Glucose (TyG) Index Is Associated with 1-Hour Glucose Levels during an OGTT

Mattia Massimino  1 , Giuseppe Monea  1 , Giuseppe Marinaro  1 , Mariangela Rubino  1 , Elettra Mancuso  1 , Gaia Chiara Mannino  1 , Francesco Andreozzi  1   2
Affiliations

The Triglycerides and Glucose (TyG) Index Is Associated with 1-Hour Glucose Levels during an OGTT

Mattia Massimino et al. Int J Environ Res Public Health. .

Abstract

Background and objectives: Among individuals with normal glucose tolerance (NGT), subjects with high levels of plasma glucose (≥155 mg/dL) at sixty minutes during an oral glucose tolerance test (1h-OGTT) are at an increased risk of developing type 2 diabetes. We investigated the association between the triglycerides and glucose (TyG) index, a novel marker of insulin resistance, with 1h-OGTT glucose plasma concentrations.

Material and methods: 1474 non-diabetic Caucasian subjects underwent a 75 g OGTT and were divided into two groups according to the cutoff 1h-OGTT plasma glucose < 155 mg/dL (NGT-1h-low) and ≥ 155 mg/dL (NGT-1h-high). The TyG index was calculated as ln [fasting triglycerides (milligrams per deciliter) × fasting blood glucose (milligrams per deciliter)/2]. Multivariable linear and logistic regression analyses were used to establish the contribution of the TyG index to the variability of 1h-OGTT glucose, and how the former affected the risk of being NGT-1h-high.

Results: 1004 individuals were NGT-1h-low and 470 were NGT-1h-high. The TyG index was higher for NGT-1h-high (p = 0.001) individuals, and it was an independent factor influencing 1h-OGTT glycemia (β = 0.191, p < 0.001) after correcting for age, sex, and BMI. The TyG index was the strongest marker associated with the risk of being NGT-1h-high (OR = 1.703, CI 95% 1.34-2.17, p < 0.001) when compared with FPG (OR = 1.054, CI 95% 1.04-1.07, p < 0.001) and the HOMA-IR (OR = 1.156, CI 95% 1.08-1.23, p < 0.001).

Conclusions: Our study demonstrated that the TyG index, an efficient and cost-effective marker of insulin resistance, is associated with the variability of early post-challenge glucose levels and is an independent marker of being NGT-1h-high.

Keywords: 1 h post-load glucose; impaired glucose tolerance; insulin resistance; prediabetes; triglyceride–glucose index.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Receiver–operating characteristic (ROC) curve for the accuracy of the TyG index at discriminating NGT-1h-high individuals from NGT-1h-low ones. The accuracy of the TyG index was 61.5% (AUC = 0.615, p < 0.001).
See this image and copyright information in PMC

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