Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec 24;12(1):143.
doi: 10.3390/jcm12010143.

Clinical Characteristics and Predictors of In-Hospital Mortality of Patients Hospitalized with COVID-19 Infection

Leszek Gromadziński  1 , Maciej Żechowicz  1 , Beata Moczulska  1 , Michał Kasprzak  2 , Klaudyna Grzelakowska  2 , Paulina Nowek  1 , Dominika Stępniak  1 , Natalia Jaje-Rykowska  1 , Aleksandra Kłosińska  3 , Mikołaj Pożarowszczyk  3 , Aleksandra Wochna  3 , Adam Kern  1 , Jerzy Romaszko  4 , Agata Sobacka  2 , Przemysław Podhajski  2 , Aldona Kubica  2 , Jacek Kryś  2 , Maciej Piasecki  2 , Piotr Lackowski  2 , Małgorzata Jasiewicz  2 , Eliano Pio Navarese  2 , Jacek Kubica  2
Affiliations

Clinical Characteristics and Predictors of In-Hospital Mortality of Patients Hospitalized with COVID-19 Infection

Leszek Gromadziński et al. J Clin Med. .

Abstract

Background: The identification of parameters that would serve as predictors of prognosis in COVID-19 patients is very important. In this study, we assessed independent factors of in-hospital mortality of COVID-19 patients during the second wave of the pandemic. Material and methods: The study group consisted of patients admitted to two hospitals and diagnosed with COVID-19 between October 2020 and May 2021. Clinical and demographic features, the presence of comorbidities, laboratory parameters, and radiological findings at admission were recorded. The relationship of these parameters with in-hospital mortality was evaluated. Results: A total of 1040 COVID-19 patients (553 men and 487 women) qualified for the study. The in-hospital mortality rate was 26% across all patients. In multiple logistic regression analysis, age ≥ 70 years with OR = 7.8 (95% CI 3.17−19.32), p < 0.001, saturation at admission without oxygen ≤ 87% with OR = 3.6 (95% CI 1.49−8.64), p = 0.004, the presence of typical COVID-19-related lung abnormalities visualized in chest computed tomography ≥40% with OR = 2.5 (95% CI 1.05−6.23), p = 0.037, and a concomitant diagnosis of coronary artery disease with OR = 3.5 (95% CI 1.38−9.10), p = 0.009 were evaluated as independent risk factors for in-hospital mortality. Conclusion: The relationship between clinical and laboratory markers, as well as the advancement of lung involvement by typical COVID-19-related abnormalities in computed tomography of the chest, and mortality is very important for the prognosis of these patients and the determination of treatment strategies during the COVID-19 pandemic.

Keywords: COVID-19; SARS-CoV-2 infection; mortality; prognosis; risk factors.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study flowchart.
See this image and copyright information in PMC

References

    1. Gorbalenya A.E., Baker S.C., Baric R.C., de Groot R.J., Drosten C., Gulyaeva A.A., Haagmans B.L., Lauber C., Leontovich A.M., Neuman B.W., et al. The species severe acute respiratory syndrome- related coronavirus: Classifying 2019-nCoV and naming it SARS-CoV-2. Nat. Microbiol. 2020;5:536–544. - PMC - PubMed
    1. Regina J., Papadymitriou-Olivgeris M., Burger R., le Pogam M.A., Niemi T., Filippidis P., Tschopp J., Desgranges F., Viala B., Kampouri E., et al. Epidemiology, risk factors and clinical course of SARS-CoV-2 infected patients in a Swiss University Hospital: An observational retrospective study. PLoS ONE. 2020;15:e0240781. doi: 10.1371/journal.pone.0240781. - DOI - PMC - PubMed
    1. Docherty A.B., Harrison E.M., Green C.A., Hardwick H.E., Pius R., Norman L., Holden K.A., Read J.M., Dondelinger F., Carson G., et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO clinical characterisation protocol: Prospective observational cohort study. BMJ. 2020;369:m1985. doi: 10.1136/bmj.m1985. - DOI - PMC - PubMed
    1. Galloway J.B., Norton S., Barker R.D., Brookes A., Carey I., Clarke B.D., Jina R., Reid C., Russell M.D., Sneep R., et al. A clinical risk score to identify patients with COVID-19 at high risk of critical care admission or death: An observational cohort study. J. Infect. 2020;81:282–288. doi: 10.1016/j.jinf.2020.05.064. - DOI - PMC - PubMed
    1. Ruscica M., Macchi C., Iodice S., Tersalvi G., Rota I., Ghidini S., Terranova L., Valenti L., Amati F., Aliberti S., et al. Prognostic parameters of in-hospital mortality in COVID-19 patients—An Italian experience. Eur. J. Clin. Investig. 2021;51:e13629. doi: 10.1111/eci.13629. - DOI - PMC - PubMed

LinkOut - more resources