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. 2023 Jan 1;28(1):349.
doi: 10.3390/molecules28010349.

Mineral Profile, Antioxidant, Anti-Inflammatory, Antibacterial, Anti-Urease and Anti-α-Amylase Activities of the Unripe Fruit Extracts of Pistacia atlantica

Mokhtar Benmohamed  1 , Hamid Guenane  1 , Mohammed Messaoudi  2   3 , Wafa Zahnit  4 , Chukwuebuka Egbuna  5 , Majid Sharifi-Rad  6 , Amina Chouh  7   8 , Bachir Ben Seghir  3 , Abdelkrim Rebiai  3 , Sihem Boubekeur  9 , Tarek Azli  10 , Mohamed Harrat  1 , Barbara Sawicka  11 , Maria Atanassova  12 , Mohamed Yousfi  1
Affiliations

Mineral Profile, Antioxidant, Anti-Inflammatory, Antibacterial, Anti-Urease and Anti-α-Amylase Activities of the Unripe Fruit Extracts of Pistacia atlantica

Mokhtar Benmohamed et al. Molecules. .

Abstract

Pistacia Atlantica in folk medicine is used by Algerian traditional healers for treating a wide variety of diseases and conditions including dyspepsia, digestive problems, peptic ulcers, and, in particular, inflammatory diseases. The present study aimed to assess the phytochemical composition, in vitro antioxidant activity (using 2,2-diphenyl-1-picrylhydrazyl (DPPH), ABTS+, and reducing power methods), enzyme inhibitory activity (towards α-amylase and urease), antibacterial activity, and in vivo anti-inflammatory activity of the unripe fruit extracts of Pistacia atlantica collected from different parts of the Djelfa region of Algeria. According to the findings, various aqueous extracts exhibited significant antioxidant and enzymatic activities in all tests, but showed that they have a weak inhibitory effect against all tested bacterial strains. Twenty-one minerals comprising both macro- and microelements (Ba, Br, Ca, Cl, Co, Cr, Cs, Eu, Fe, K, Mg, Mn, Mo, Na, Rb, Sb, Sc, Sr, Th, U, and Zn) were determined using the technique of neutron activation analysis (INAA). The result indicates that the concentration of the mineral element is close to the minimal FAO recommendation. In addition, the result revealed significant anti-inflammatory activities. The data generated can be a valuable source of information for the pharmaceutical industry and medical research. These results suggest that the unripe fruit extracts of Pistacia atlantica have an appropriate potential to be utilized across a wide range of contexts as an agent with multifunctional uses, as well as a natural remedy for other physiological diseases.

Keywords: Pistacia atlantica; antioxidant activity; biological activity; mineral; total phenol; unripe fruit.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The geographical location of the sample collection.
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