One giant leap for cephalexin dosing, one small step for antimicrobial stewardship

Paul Ken Leong Chin^{1

2}, Martin Than³, Stephen Chambers⁴

Affiliations

¹ Department of Medicine, University of Otago, Private Bag 4345, Christchurch, New Zealand. paul.chin@otago.ac.nz.
² Department of Clinical Pharmacology, Te Whatu Ora Health New Zealand, Waitaha Canterbury, Christchurch, New Zealand. paul.chin@otago.ac.nz.
³ Emergency Department, Christchurch Hospital, Christchurch, New Zealand.
⁴ Department of Pathology, University of Otago, Christchurch, New Zealand.

Editorial

Paul Ken Leong Chin et al. CJEM. 2023 Jan.

. 2023 Jan;25(1):7-8.

doi: 10.1007/s43678-022-00442-6.

Paul Ken Leong Chin^{1

2}, Martin Than³, Stephen Chambers⁴

¹ Department of Medicine, University of Otago, Private Bag 4345, Christchurch, New Zealand. paul.chin@otago.ac.nz.
² Department of Clinical Pharmacology, Te Whatu Ora Health New Zealand, Waitaha Canterbury, Christchurch, New Zealand. paul.chin@otago.ac.nz.
³ Emergency Department, Christchurch Hospital, Christchurch, New Zealand.
⁴ Department of Pathology, University of Otago, Christchurch, New Zealand.

No abstract available

Keywords: Cellulitis; Cephalexin; Emergency department; Pharmacokinetics.

References

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1. Craig WA. Pharmacokinetic/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men. Clin Infect Dis. 1998;26:1–10. - DOI
1. Everts RJ, Gardiner SJ, Zhang M, et al. Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. J Infect. 2021;83:182–9. - DOI
1. Yadav K. 2022 High-Dose Cephalexin for Cellulitis: A Pilot Randomized Controlled Trial. CJEM.
1. Dalen D, Fry A, Campbell SG, Eppler J, Zed PJ. Intravenous cefazolin plus oral probenecid versus oral cephalexin for the treatment of skin and soft tissue infections: a double-blind, non-inferiority, randomised controlled trial. Emerg Med J. 2018;35:492–8. - DOI