Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb 1;13(2):a041309.
doi: 10.1101/cshperspect.a041309.

Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions

Christelle Monville  1   2 , Olivier Goureau  3 , Karim Ben M'Barek  1   2   4
Affiliations
Review

Photoreceptor Cell Replacement Using Pluripotent Stem Cells: Current Knowledge and Remaining Questions

Christelle Monville et al. Cold Spring Harb Perspect Med. .

Abstract

Retinal degeneration is an increasing global burden without cure for the majority of patients. Once retinal cells have degenerated, vision is permanently lost. Different strategies have been developed in recent years to prevent retinal degeneration or to restore sight (e.g., gene therapy, cell therapy, and electronic implants). Herein, we present current treatment strategies with a focus on cell therapy for photoreceptor replacement using human pluripotent stem cells. We will describe the state of the art and discuss obstacles and limitations observed in preclinical animal models as well as future directions to improve graft integration and functionality.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Scheme describing different therapeutic options envisioned to prevent degeneration or restore vision of patients with retinal degenerative disorders. (PR) Photoreceptors, (EVs) extracellular vesicles.
See this image and copyright information in PMC

References

    1. Aboualizadeh E, Phillips MJ, McGregor JE, DiLoreto DA, Strazzeri JM, Dhakal KR, Bateman B, Jager LD, Nilles KL, Stuedemann SA, et al. 2020. Imaging transplanted photoreceptors in living nonhuman primates with single-cell resolution. Stem Cell Reports 15: 482–497. 10.1016/j.stemcr.2020.06.019 - DOI - PMC - PubMed
    1. Al-Khersan H, Hussain RM, Ciulla TA, Dugel PU. 2019. Innovative therapies for neovascular age-related macular degeneration. Exp Opin Pharmacother 20: 1879–1891. 10.1080/14656566.2019.1636031 - DOI - PubMed
    1. Assawachananont J, Mandai M, Okamoto S, Yamada C, Eiraku M, Yonemura S, Sasai Y, Takahashi M. 2014. Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice. Stem Cell Reports 2: 662–674. 10.1016/j.stemcr.2014.03.011 - DOI - PMC - PubMed
    1. Auffarth GU, Tetz MR, Krastel H, Blankenagel A, Völcker HE. 1997. Complicated cataracts in various forms of retinitis pigmentosa. Type and incidence. Ophthalmologe 94: 642–646. 10.1007/s003470050175 - DOI - PubMed
    1. Barber AC, Hippert C, Duran Y, West EL, Bainbridge JW, Warre-Cornish K, Luhmann UF, Lakowski J, Sowden JC, Ali RR, et al. 2013. Repair of the degenerate retina by photoreceptor transplantation. Proc Natl Acad Sci 110: 354–359. 10.1073/pnas.1212677110 - DOI - PMC - PubMed

Publication types

LinkOut - more resources