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Case Reports
. 2022 Dec 22;8(12):e12476.
doi: 10.1016/j.heliyon.2022.e12476. eCollection 2022 Dec.

Scedosporium apiospermum invasive rhinosinusitis in an elderly patient: diagnosis and treatment

Yibo Liang  1   2   3   4   5 , Xin Xiong  1   2   3   4   5 , Chenting Zhang  1   2   3   4   5   6 , Wei Wang  1   2   3   4   5   6 , Guimin Zhang  1   2   3   4   5   6
Affiliations
Case Reports

Scedosporium apiospermum invasive rhinosinusitis in an elderly patient: diagnosis and treatment

Yibo Liang et al. Heliyon. .

Abstract

Scedosporium apiospermum is a ubiquitous organism present in the environment and is rarely identified in rhinosinusitis. We report a case of invasive rhinosinusitis with Scedosporium apiospermum which made a definite diagnosis by metagenomic next-generation sequencing (mNGS) from a biopsy sample. The resection of the Scedosporium apiospermum pathological mass was performed with low-temperature plasma radiofrequency ablation. Six months of continuous oral voriconazole treatment was followed. The patient was asymptomatic with no signs of recurrence during the next 1-year follow-up.

Keywords: Invasive fungal rhinosinusitis; Metagenomic next-generation sequencing; Scedosporium apiospermum.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The flowchart for diagnosis and treatment of this case.
Figure 2
Figure 2
Preoperative CT scan showed that the skull base was involved by the olfactory area mass, and the bone of the skull base was damaged (A). MRI showed that the meninges were involved (B). A Scedosporium apiospermum mass was identified in the olfactory area during the surgical operation (C, black arrow indicates lesion location).
Figure 3
Figure 3
The Scedosporium apiospermum genome sequences mapping by mNGS.
Figure 4
Figure 4
GMS-stained results showed some black particles but could not find mycelia (A). MRI showed that a small mass remained 2 weeks after the surgery (B). The lesion completely disappeared after surgery and voriconazole treatment (C). ∗ indicates sphenoid sinus.
See this image and copyright information in PMC

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References

    1. Swami T., Pannu S., Kumar M., Gupta G. Chronic invasive fungal rhinosinusitis by Paecilomyces variotii: a rare case report. Indian J. Med. Microbiol. 2016;34(1):103–106. - PubMed
    1. Montone K.T., Livolsi V.A., Feldman M.D., Palmer J., Chiu A.G., Lanza D.C., et al. Fungal rhinosinusitis: a retrospective microbiologic and pathologic review of 400 patients at a single university medical center. Int. J. Otolaryngol. 2012;2012 - PMC - PubMed
    1. deShazo R.D., O'Brien M., Chapin K., Soto-Aguilar M., Gardner L., Swain R. A new classification and diagnostic criteria for invasive fungal sinusitis. Arch. Otolaryngol. Head Neck Surg. 1997;123(11):1181–1188. - PubMed
    1. Fung M., Babik J., Humphreys I.M., Davis G.E. Diagnosis and treatment of acute invasive fungal sinusitis in cancer and transplant patients. Curr. Infect. Dis. Rep. 2019;21(12):53. - PubMed
    1. Alarifi I., Alsaleh S., Alqaryan S., Assiri H., Alsukayt M., Alswayyed M., et al. Chronic granulomatous invasive fungal sinusitis: a case series and literature review. Ear Nose Throat J. 2021;100(5_suppl):720S–727S. - PubMed

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