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Case Reports
. 2023 Jan 3;11(1):e6688.
doi: 10.1002/ccr3.6688. eCollection 2023 Jan.

Flumatinib plus venetoclax as an effective therapy for Philadelphia chromosome-positive acute myeloid leukemia: A case report

Si-Man Huang  1   2 , Tao Tao  3   4 , Chao-Ling Wan  1   2 , Tian-Mei Wu  1   2 , Han-Yu Cao  1   2 , Yan Qiu  1   2 , Xiang-Dong Shen  1   2 , Bin-Ru Wang  1   2 , Shuai-Shuai Ge  1   2 , Yan-Yan Li  1   2 , Tong-Tong Zhang  1   2 , Bing Wu  5 , Sheng-Li Xue  1   2
Affiliations
Case Reports

Flumatinib plus venetoclax as an effective therapy for Philadelphia chromosome-positive acute myeloid leukemia: A case report

Si-Man Huang et al. Clin Case Rep. .

Abstract

Philadelphia chromosome-positive acute myeloid leukemia (Ph + AML) is a rare type of AML with a low survival rate and poor prognosis. We first report a Ph + AML patient who remained in long-term remission after the combination of flumatinib and venetoclax, which could provide corresponding treatment ideas for clinical practice.

Keywords: Philadelphia chromosome‐positive acute myeloid leukemia; flumatinib; regimen; venetoclax.

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Conflict of interest statement

The authors declare no competing interests.

Figures

FIGURE 1
FIGURE 1
(A) Dynamic changes in blood cell count during ven + flu treatment. (B) Treatment process of the patient. CR, complete remission; PR, partial remission; NR, non‐remission; HA, homoharringtonine and cytarabine; Aza, 5‐azacitidine; Ara, cytarabine; Ima, imatinib; Ven, venetoclax; Flu, flumatinib; BM, bone marrow blast cell. BCR::ABL1, the presence of BCR::ABL1 fusion gene calculated with standard materials was normalized with respect to the number of ABL1 transcripts and expressed as copy numbers per 1 × 104 copies of abl.
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