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Review
. 2022 Jul 1;19(6):244-247.
doi: 10.1002/cld.1218. eCollection 2022 Jun.

The clinical value of angiopoietin-2 in liver diseases

Affiliations
Review

The clinical value of angiopoietin-2 in liver diseases

Maham Farshidpour et al. Clin Liver Dis (Hoboken). .

Abstract

Content available: Audio Recording.

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Conflict of interest statement

Nothing to report.

Figures

FIGURE 1
FIGURE 1
Schematic showing the signal transduction with Tie2 and Ang1/2. Proposed model showing stimulatory effect (green arrows) and inhibitory effect (red arrows). Tie2 is expressed on the blood vessel and, when Ang1 binding causes a stimulatory effect, thus downstream signal transduction. Ang2 has an inhibitory effect on Ang1. Ang1, Angiopoietin 1; Ang2, Angiopoietin 2; VEGF, vascular endothelial Growth factor; NF‐κβ, nuclear factor kappa‐light‐chain‐enhancer of activated B cells; PI3K/AKT, Phosphatidylinositol‐3‐Kinase/Protein kinase B

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References

    1. Yamashita S, Kudo A, Kawakami H, Okada Y. Mechanisms of angiogenic suppression in uteri exposed to diethylstilbestrol neonatally in the mouse. Biol Reprod. 2013;88:116. - PubMed
    1. Akwii RG, Sajib MS, Zahra FT, Mikelis CM. Role of angiopoietin‐2 in vascular physiology and pathophysiology. Cells. 2019;8:471. - PMC - PubMed
    1. Elpek GO. Angiogenesis and liver fibrosis. World J Hepatol. 2015;7:377–91. - PMC - PubMed
    1. Lefere S, Van de Velde F, Hoorens A, Raevens S, Van Campenhout S, Vandierendonck A, et al. Angiopoietin‐2 promotes pathological angiogenesis and is a therapeutic target in murine nonalcoholic fatty liver disease. Hepatology. 2019;69:1087–104. - PubMed
    1. Olsson A‐K, Dimberg A, Kreuger J,Claesson‐Welsh L. VEGF receptor signalling ‐ in control of vascular function. Nat Rev Mol Cell Biol. 2006;7:359–71. - PubMed