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. 2022 Dec 22:13:1061879.
doi: 10.3389/fmicb.2022.1061879. eCollection 2022.

The clinical characteristics and risk factors for severe COVID-19 in patients with COVID-19 and tuberculosis coinfection

Yang Wang  1 , Yanping Chen  2 , Lina Gu  3 , Lixin Lou  1 , Jian Zhang  4 , Kaiyu Zhang  1
Affiliations

The clinical characteristics and risk factors for severe COVID-19 in patients with COVID-19 and tuberculosis coinfection

Yang Wang et al. Front Microbiol. .

Abstract

Background: Under the wave of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) variant Omicron epidemic, the number of infectious cases has increased dramatically in Jilin Province, China since March 2022.The clinical features and severity of SARS-CoV-2 Omicron variant infection in tuberculosis (TB) patients are not yet clear.

Methods: Data were obtained from 153 patients with the Omicron variant and TB coinfection and 153 non-TB COVID-19 patients who had been hospitalized at Changchun Infectious Disease Hospital from March to June 2022.

Results: Among these coinfection patients, 17 patients showed COVID-19-related pneumonia on chest imaging and 11 were diagnosed with severe COVID-19. The median duration of SARS-CoV-2 clearance was 13 days. The negative conversion time was associated with age, COVID-19-related pneumonia and antibody IgG. A higher white blood cell count, a lower lymphocyte percentage, a higher CRP level, and a higher D-dimer level were found in the severe group. Age and increased PCT were individual risk factors for the severity of COVID-19. Compared with the non-TB patients, the coinfection patients had higher severity of COVID-19 and the elder coinfection patients had a longer negative conversion time.

Conclusion: This study found an association between age, pneumonia, antibody IgG and RNA negative conversion time in COVID-19 and TB coinfection patients, and age and increased PCT were risk factors for the severity of COVID-19.

Keywords: COVID-19; RNA negative conversion time; clinical characteristics; coinfection; epidemiological; tuberculosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Demographic, epidemiological, and clinical characteristics of 153 COVID-19 and TB coinfection patients. Diabetes, Coronary heart disease, Hypertension, Chronic lung disease, Tumor, Cerebral infarction, HIV infection. (A) Age, (B) Underlying conditions, (C) Symptoms, (D) COVID-19 type, (E) Vaccination.
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