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Review
. 2022 Dec 23:12:1081997.
doi: 10.3389/fonc.2022.1081997. eCollection 2022.

Advances in peptides encoded by non-coding RNAs: A cargo in exosome

Jing Yang  1   2   3 , Mengxiao Liu  1   2   3 , Xidong Fang  1   2   3 , Huiyun Zhang  1   2   3 , Qian Ren  2   3 , Ya Zheng  2   3 , Yuping Wang  2   3 , Yongning Zhou  2   3
Affiliations
Review

Advances in peptides encoded by non-coding RNAs: A cargo in exosome

Jing Yang et al. Front Oncol. .

Abstract

The metastasis of malignant tumors determines patient prognosis. This is the main reason for the poor prognosis of patients with cancer and the most challenging aspect of treating malignant tumors. Therefore, it is important to identify early tumor markers and molecules that can predict patient prognosis. However, there are currently no molecular markers with good clinical accuracy and specificity. Many non-coding RNA (ncRNAs)have been identified, which can regulate the process of tumor development at multiple levels. Interestingly, some ncRNAs are translated to produce functional peptides. Exosomes act as signal carriers, are encapsulated in nucleic acids and proteins, and play a messenger role in cell-to-cell communication. Recent studies have identified exosome peptides with potential diagnostic roles. This review aims to provide a theoretical basis for ncRNA-encoded peptides or proteins transported by exosomes and ultimately to provide ideas for further development of new diagnostic and prognostic cancer markers.

Keywords: cancer; exosome; non-coding RNA; peptide; translation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Role of ncRNAs-encoded peptides/protein in cancers. (By Figdraw).
Figure 2
Figure 2
Tumor-derived exosomal ncRNAs function. (By Figdraw).
See this image and copyright information in PMC

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References

    1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. . Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin (2021) 71:209–49. doi: 10.3322/caac.21660 - DOI - PubMed
    1. Rajagopalan D, Jha S. An epi(c) genetic war: Pathogens, cancer and human genome. Biochim Biophys Acta Rev Cancer (2018) 1869:333–45. doi: 10.1016/j.bbcan.2018.04.003 - DOI - PubMed
    1. Costa FF. Non-coding RNAs: could they be the answer? Brief Funct Genomics (2011) 10:316–9. doi: 10.1093/bfgp/elq029 - DOI - PubMed
    1. Ashar FN, Mitchell RN, Albert CM, Newton-Cheh C, Brody JA, Müller-Nurasyid M, et al. . A comprehensive evaluation of the genetic architecture of sudden cardiac arrest. Eur Heart J (2018) 39:3961–9. doi: 10.1093/eurheartj/ehy474 - DOI - PMC - PubMed
    1. Rahimian N, Razavi ZS, Aslanbeigi F, Mirkhabbaz AM, Piroozmand H, Shahrzad MK, et al. . Non-coding RNAs related to angiogenesis in gynecological cancer. Gynecol Oncol (2021) 161:896–912. doi: 10.1016/j.ygyno.2021.03.020 - DOI - PubMed

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